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Pseudosarcomatous Myofibroblastic Proliferations

  • Living reference work entry
  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 34 Accesses

Synonyms

Inflammatory pseudotumor; Postoperative spindle cell nodule; Pseudomalignant spindle cell proliferation; Pseudosarcomatous fibromyxoid tumor; Visceral fasciitis

Definition

A benign lesion of myofibroblasts showing overlap with nodular fasciitis, inflammatory myofibroblastic tumor, and granulation tissue.

Clinical Features

  • Incidence

    Rare.

  • Age

    Mainly seen in adults.

  • Sex

    No gender predilection.

  • Site

    The mucosal surface of the genitourinary tract is mostly affected, but the lesions can occur at any mucosal site of the gastrointestinal tract and head and neck area (Proppe et al. 1984; Harik et al. 2006).

  • Treatment

    Surgical excision usually is curative.

  • Outcome

    These lesions are benign but can occasionally recur.

Macroscopy

The lesion usually presents as polypoid, exophytic, and ulcerated masses.

Microscopy

Plump, elongated myofibroblasts are arranged in loose fascicles (Fig. 1). Some cells have prominent eccentric cytoplasm and mimic rhabdomyoblasts (Fig. 2). The nuclei are...

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References

  • Harik, L. R., Merino, C., Coindre, J. M., Amin, M. B., Pedeutour, F., & Weiss, S. W. (2006). Pseudosarcomatous myofibroblastic proliferations of the bladder: A clinicopathologic study of 42 cases. The American Journal of Surgical Pathology, 30, 787–794.

    Article  Google Scholar 

  • Jebastin, J. A. S., Smith, S. C., Perry, K. D., Gupta, N. S., Alanee, S., Carskadon, S., Chitale, D. A., Palanisamy, N., & Williamson, S. R. (2018). Pseudosarcomatous myofibroblastic proliferations of the genitourinary tract are genetically different from nodular fasciitis and lack USP6, ROS1 and ETV6 gene rearrangements. Histopathology, 73, 321–326.

    Article  Google Scholar 

  • Marino-Enriquez, A., & Hornick, J. L. (2019). Pseudosarcomatous myofibroblastic proliferation. In J. L. Hornick (Ed.), Practical soft tissue pathology (pp. 25–27). Philadelphia: Elsevier.

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  • Proppe, K. H., Scully, R. E., & Rosai, J. (1984). Postoperative spindle cell nodules of genitourinary tract resembling sarcomas. A report of eight cases. The American Journal of Surgical Pathology, 8, 101–108.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Imaging and Pathology, Translational Cell and Tissue Research, KU Leuven, University of Leuven, Leuven, Belgium

    Raf Sciot

Authors
  1. Raf Sciot
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Corresponding author

Correspondence to Raf Sciot .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Cite this entry

Sciot, R. (2020). Pseudosarcomatous Myofibroblastic Proliferations. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5459-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_5459-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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