Synonyms
Garrod’s Nodes (Hasbún et al. 2019).
Definition
Proliferations of myofibroblastic cells, occurring in the dorsal aspect of the phalangeal joints.
Clinical Features
Incidence
They are uncommon lesions, frequently associated with palmar and/or plantar fibromatosis (Fetsch et al. 2005). Pachydermodactyly is an uncommon acquired form of digital fibromatosis affecting adolescent boys (Prieto et al. 2011). Knuckle pads can occur in the contest of Bart-Pumphrey syndrome, an autosomal dominant disease associated with missense mutations in the GJB2 gene and characterized by knuckle pads, sensorineural hearing loss, palmoplantar keratoacanthoma, and leukonychia (Richard et al. 2004).
Age
The lesion generally affects adult patients, in the forth to sixth decades of life.
Sex
Men are more frequently affected.
Site
The lesions occur in the dorsal aspect over the extensor surface of the interphalangeal or metacarpophalangeal joints (Goldblum et al. 2014).
Treatment
No effective treatment...
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References and Further Reading
Fetsch, J. F., Laskin, W. B., & Miettinen, M. (2005). Palmar-plantar fibromatosis in children and preadolescents: A clinicopathologic study of 56 cases with newly recognized demographics and extended follow-up information. The American Journal of Surgical Pathology, 29(8), 1095–1105.
Goldblum, J. R., Folpe, A. L., & Weiss, S. W. (2014). Soft tissue tumors. Philadelphia: Elsevier Saunders.
Hasbún, C., Sandoval, M., & Curi, M. (2019). A novel treatment for idiopathic knuckle pads with cantharidin-podophylotoxin-salicylic acid. Pediatric Dermatology, 36(4), 544–545.
Prieto, D., Gallego, E., López-Navarro, N., Matilla, A., & Herrera-Ceballos, E. (2011). Pachydermodactyly: An uncommon acquired digital fibromatosis. Journal of Clinical Rheumatology, 17(1), 53–54.
Richard, G., Brown, N., Ishida-Yamamoto, A., & Krol, A. (2004). Expanding the phenotypic spectrum of Cx26 disorders: Bart-Pumphrey syndrome is caused by a novel missense mutation in GJB2. The Journal of Investigative Dermatology, 123(5), 856–863.
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Gambarotti, M. (2020). Knuckle Pads. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5413-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_5413-1
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