Synonyms
Definition
A mesenchymal tumor composed of modified smooth muscle cells like those of the normal glomus body.
Clinical Features
Incidence
Glomangioma is rare accounting for less than 2% of all soft tissue tumors (Shugart 1963).
Age
Glomangioma usually affects middle-aged adults. However, it may occur at any age.
Sex
Glomangiomas are equally distributed among men and women. There is a female predominance only for subungual lesions (female-to-male ratio, 3:1) (Tsuneyoshi and Enjoji 1982).
Site
Glomangiomas almost always develop within the skin or the superficial soft tissues. However, cases occur in the deep soft tissue or in the viscera. Described throughout the body, the vast majority of glomangiomas affect the distal extremities, especially the fingers (most of all in the subungual region), the hand, the wrist, and the foot. Malignant glomangiomas are more commonly deep-seated than benign tumors (Folpe et al. 2001).
Treatment...
References and Further Reading
Amyere, M., Aerts, V., Brouillard, P., McIntyre, B. A., Duhoux, F. P., Wassef, M., … Boon, L. M. (2013). Somatic uniparental isodisomy explains multifocality of glomuvenous malformations. The American Journal of Human Genetics, 92(2), 188–196.
Brems, H., Park, C., Maertens, O., Pemov, A., Messiaen, L., Upadhyaya, M., … Sloan, J. L. (2009). Glomus tumors in neurofibromatosis type 1: Genetic, functional, and clinical evidence of a novel association. Cancer Research, 69(18), 7393–7401.
Folpe, A. L., Fanburg-Smith, J. C., Miettinen, M., & Weiss, S. W. (2001). Atypical and malignant glomus tumors: Analysis of 52 cases, with a proposal for the reclassification of glomus tumors. The American Journal of Surgical Pathology, 25(1), 1–12.
Gombos, Z., & Zhang, P. J. (2008). Glomus tumor. Archives of Pathology & Laboratory Medicine, 132(9), 1448–1452.
Shugart, R. R. (1963). Glomus tumor. Surgery, Gynecology & Obstetrics, 117, 334–340.
Tsuneyoshi, M., & Enjoji, M. (1982). Glomus tumor. A clinicopathologic and electron microscopic study. Cancer, 50(8), 1601–1607.
Vasisht, B., Watson, H. K., Joseph, E., & Lionelli, G. T. (2004). Digital glomus tumors: A 29-year experience with a lateral subperiosteal approach. Plastic and Reconstructive Surgery, 114(6), 1486–1489.
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Cappellesso, R. (2020). Glomangioma, Glomangiomyoma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5394-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_5394-1
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