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Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma

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  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

Synonyms

Atypical lipoma

Definition

Atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDLPS) represents the largest subgroup of adipocytic malignancies (Enzinger and Winslow 1962). The terms ALT and WDLPS are synonyms, describing locally aggressive lesions showing identical morphological and genetical features (Weiss and Rao 1992; Lucas et al. 1994). The term ALT is recommended for lesions arising at anatomic locations for which complete surgical excision is feasible and curative, whereas the term WDLPS is preferred for lesions arising at central body sites, such as the retroperitoneum, for which multivisceral resection is considered, and the potential for disease progression is greater. The tumor is composed either entirely or partly of an adipocytic proliferation showing nuclear atypia in both adipocytes and stromal cells. In the current WHO, three histological variants of ALT/WDLPS are recognized (Evans 2007): (1) adipocytic (lipoma-like), (2) sclerosing, and (3)...

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References and Further Reading

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Authors and Affiliations

  1. Department of Pathology, Azienda Ospedale Università Padova, Padova, Italy

    Marta Sbaraglia

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  1. Marta Sbaraglia
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Correspondence to Marta Sbaraglia .

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  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Sbaraglia, M. (2020). Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5352-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_5352-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

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