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Angiomatoid Fibrous Histiocytoma

  • Living reference work entry
  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 31 Accesses

Synonyms

Angiomatoid malignant fibrous histiocytoma

Definition

Angiomatoid fibrous histiocytoma (AFH) is a rare lesion of uncertain differentiation, regarded as an intermediate malignant potential (rarely metastasizing), tumor (Enzinger 1979). AFH is not related either with high-grade pleomorphic sarcoma or fibrous histiocytoma of the skin.

Clinical Features

  • Incidence

    AFH is extremely rare, accounting approximately for 0.3% of all mesenchymal tumors (Enzinger 1979; Fanburg-Smith and Miettinen 1999).

  • Age

    A wide age range has been reported but typically occurs in young people with a mean age of 20 years (Enzinger 1979; Fanburg-Smith and Miettinen 1999).

  • Sex

    There is no significant gender predilection (Enzinger 1979; Fanburg-Smith and Miettinen 1999).

  • Site

    AFH occur most often in deep dermis and subcutis of the extremities, followed by the trunk and head and neck region (Enzinger 1979; Fanburg-Smith and Miettinen 1999). The majority of cases involve anatomic sites rich in lymph nodes....

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References and Further Reading

  • Antonescu, C. R., Dal Cin, P., Nafa, K., et al. (2007). EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma. Genes, Chromosomes & Cancer, 46, 1051–1060.

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  • Cheah, A. L., Zou, Y., Lanigan, C., et al. (2019). ALK expression in angiomatoid fibrous histiocytoma: A potential diagnostic pitfall. The American Journal of Surgical Pathology, 43, 93–101.

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  • Chen, G., Folpe, A. L., Colby, T. V., et al. (2011). Angiomatoid fibrous histiocytoma: Unusual sites and unusual morphology. Modern Pathology, 24, 1560–1570.

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  • Costa, M. J., & Weiss, S. W. (1990). Angiomatoid malignant fibrous histiocytoma. A follow-up study of 108 cases with evaluation of possible histologic predictors of outcome. The American Journal of Surgical Pathology, 14, 1126–1132.

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  • Enzinger, F. M. (1979). Angiomatoid malignant fibrous histiocytoma: A distinct fibrohistiocytic tumor of children and young adults simulating a vascular neoplasm. Cancer, 44, 2147–2157.

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  • Fanburg-Smith, J. C., & Miettinen, M. (1999). Angiomatoid “malignant” fibrous histiocytoma: A clinicopathologic study of 158 cases and further exploration of the myoid phenotype. Human Pathology, 30, 1336–1343.

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  • Fletcher, C. D. (1991). Angiomatoid “malignant fibrous histiocytoma”: An immunohistochemical study indicative of myoid differentiation. Human Pathology, 22, 563–568.

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  • Hallor, K. H., Mertens, F., Jin, Y., et al. (2005). Fusion of the EWSR1 and ATF1 genes without expression of the MITF-M transcript in angiomatoid fibrous histiocytoma. Genes, Chromosomes & Cancer, 44, 97–102.

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  • Kao, Y. C., Lan, J., Tai, H. C., et al. (2014). Angiomatoid fibrous histiocytoma: Clinicopathological and molecular characterization with emphasis on variant histomorphology. Journal of Clinical Pathology, 67, 210–215.

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  • Raddaoui, E., Donner, L. R., & Panagopoulos, I. (2002). Fusion of the FUS and ATF1 genes in a large, deep-seated angiomatoid fibrous histiocytoma. Diagnostic Molecular Pathology, 11, 157–162.

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  • Rossi, S., Szuhai, K., Ijszenga, M., et al. (2007). EWSR1-CREB1 and EWSR1-ATF1 fusion genes in angiomatoid fibrous histiocytoma. Clinical Cancer Research, 13, 7322–7328.

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  • Schaefer, I. M., & Fletcher, C. D. (2014). Myxoid variant of so-called angiomatoid “malignant fibrous histiocytoma”: Clinicopathologic characterization in a series of 21 cases. The American Journal of Surgical Pathology, 38, 816–823.

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  • Waters, B. L., Panagopoulos, I., & Allen, E. F. (2000). Genetic characterization of angiomatoid fibrous histiocytoma identifies fusion of the FUS and ATF-1 genes induced by a chromosomal translocation involving bands 12q13 and 16p11. Cancer Genetics and Cytogenetics, 121, 109–116.

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Author information

Authors and Affiliations

  1. Department of Pathology, Azienda Ospedale Università Padova, Padova, Italy

    Marta Sbaraglia

Authors
  1. Marta Sbaraglia
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Corresponding author

Correspondence to Marta Sbaraglia .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Sbaraglia, M. (2020). Angiomatoid Fibrous Histiocytoma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5347-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_5347-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

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