Skip to main content
SpringerLink
Log in

CDX2

  • Living reference work entry
  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 17 Accesses

Synonyms

Caudal-type homeobox protein 2

Definition

Homeobox protein CDX2 is a protein encoded by the CDX2 gene, which is a member of the caudal-related homeobox transcription factor family.

Features

CDX2 is a homeobox domain-containing transcription factor, which plays a pivotal role in the development and differentiation of intestinal epithelial cells and maintenance of intestinal phenotype, through transcriptional regulation of multiple genes expressed in the intestinal epithelium. This complex machinery of sequentially activated genes seems to decrease cellular replication and induce differentiation to mature intestinal epithelium. CDX2 is expressed in the nucleus of intestinal epithelial cells and, in addition, in the nucleus of pancreatic centroacinar, intercalated, and intralobular duct cells (Moskaluk et al. 2003). Among digestive neuroendocrine cells, CDX2 is expressed by intestinal serotonin-producing EC-cells and by about 10% of gastrin-producing G-cells (La Rosa et al. 2004)....

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References and Further Reading

  • Bellizzi, A. M. (2013). Assigning site of origin in metastatic neuroendocrine neoplasms: A clinically significant application of diagnostic immunohistochemistry. Advances in Anatomic Pathology, 20, 285–314.

    Article  CAS  Google Scholar 

  • La Rosa, S., Rigoli, E., Uccella, S., Chiaravalli, A. M., & Capella, C. (2004). CDX2 as a marker of intestinal EC-cells and related well-differentiated endocrine tumors. Virchows Archiv, 445, 248–254.

    Article  CAS  Google Scholar 

  • Moskaluk, C. A., Zhang, H., Powell, S. M., Cerilli, L. A., Hampton, G. M., & Frierson, H. F., Jr. (2003). Cdx2 protein expression in normal and malignant human tissues: An immunohistochemical survey using tissue microarrays. Modern Pathology, 16, 913–919.

    Article  Google Scholar 

  • Uccella, S., Sessa, F., & La Rosa, S. (2015). Diagnostic approach to neuroendocrine neoplasms of the gastrointestinal tract and pancreas. Turk Patoloji Derg, 31(Suppl 1), 113–127.

    PubMed  Google Scholar 

  • Uccella, S., La Rosa, S., Volante, M., & Papotti, M. (2018). Immunohistochemical biomarkers of gastrointestinal, pancreatic, pulmonary, and thymic neuroendocrine neoplasms. Endocrine Pathology, 29, 150–168.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Pathology, University Hospital and University of Lausanne, Lausanne, Switzerland

    Stefano La Rosa

Authors
  1. Stefano La Rosa
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Stefano La Rosa .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

La Rosa, S. (2021). CDX2. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_5183-1

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-28845-1_5183-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation