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Encyclopedia of Pathology pp 1–2Cite as

Urothelial Papilloma

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Part of the book series: Encyclopedia of Pathology ((EP))

Synonyms

Papilloma

Definition

Urothelial papilloma is a benign exophytic neoplasm, characterized by a central delicate fibrovascular core lined by urothelium with normal cytology and thickness.

Clinical Features

  • Incidence

    Following the restrictive diagnostic criteria recommended by the WHO classification, urothelial papilloma represents less than 4% of papillary urothelial neoplasm (Reuter et al. 2016). Risk factors are similar to those of urothelial neoplasm, such as cigarette smoking and occupational exposure to aromatic amines.

  • Age

    It occurs in patients less than 50 years of age (mainly in young adults and children).

  • Sex

    The male to female ratio is 2:1 (Magi-Galluzzi and Epstein 2004).

  • Site

    Most tumors are located at the trigone, close to the ureteric orifices

  • Treatment

    The most common symptom is hematuria. Transurethral resection is both diagnostic and therapeutic.

  • Outcome

    Urothelial papilloma has a low incidence of recurrence (estimated between 8 and 14%) and rarely progress to...

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References and Further Reading

  • Al Bashir, S., Yilmaz, A., Gotto, G., & Trpkov, K. (2014). Long term outcome of primary urothelial papilloma: A single institution cohort. Pathology, 46, 37–40.

    Article  Google Scholar 

  • Harnden, P., Mahmood, N., & Southgate, J. (1999). Expression of cytokeratin 20 redefines urothelial papillomas of the bladder. Lancet, 353, 974–977.

    Article  CAS  Google Scholar 

  • Magi-Galluzzi, C., & Epstein, J. I. (2004). Urothelial papilloma of the bladder: A review of 34 de novo cases. The American Journal of Surgical Pathology, 28, 1615–1620.

    Article  Google Scholar 

  • Montironi, R., Lopez-Beltran, A., Scarpelli, M., et al. (2008). Morphological classification and definition of benign, preneoplastic and non-invasive neoplastic lesions of the urinary bladder. Histopathology, 53, 621–633.

    Article  CAS  Google Scholar 

  • Reuter, V. E., Algaba, F., Amin, M. B., Cao, D., Cheng, L., et al. (2016). Non-invasive urothelial lesions. In H. Moch, P. A. Humphrey, T. M. Ulbright, & V. E. Reuter (Eds.), WHO classification of tumours of the urinary system and male genital organs (pp. 99–107). Lyon: IARC.

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  • van Rhijn, B. W., Montironi, R., Zwarthoff, E. C., et al. (2002). Frequent FGFR3 mutations in urothelial papilloma. The Journal of Pathology, 198, 245–251.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Pathology Service, Champalimaud Clinical Center, Lisbon, Portugal

    Rita Canas-Marques & Antonio Lopez-Beltran

  2. Histopathology and Molecular Diagnostics, University Hospital Careggi, Florence, Italy

    Maria Rosaria Raspollini

  3. Department of Surgery and Pathology, University of Cordoba Medical School, Cordoba, Spain

    Antonio Lopez-Beltran

Authors
  1. Rita Canas-Marques
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  2. Maria Rosaria Raspollini
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  3. Antonio Lopez-Beltran
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Corresponding author

Correspondence to Antonio Lopez-Beltran .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Cite this entry

Canas-Marques, R., Raspollini, M.R., Lopez-Beltran, A. (2019). Urothelial Papilloma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4993-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4993-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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