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Encyclopedia of Pathology pp 1–3Cite as

Urothelial Dysplasia

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Part of the book series: Encyclopedia of Pathology ((EP))

Synonyms

Low-grade intra-urothelial neoplasia (not recommended); Urothelial atypia

Definition

Abnormal urothelium with cytological and architectural atypia that falls short for the diagnosis of urothelial carcinoma in situ

Clinical Features

  • Incidence

    Primary dysplasia is an uncommon finding occurring in the absence of urothelial tumors, in patients with irritative symptoms with or without hematuria. Secondary dysplasia is a common finding that occurs in patients with a history of bladder neoplasia. The incidence of dysplasia in patients with bladder carcinoma varies from 20% to 85% to 100% in patients with invasive carcinoma (Epstein et al. 2010).

  • Age

    Primary dysplasia occurs in middle-age patients; secondary dysplasia occurs in middle-age and old patients.

  • Sex

    More common in male patients

  • Site

    No specific site in the urinary tract, more common in the bladder

  • Treatment

    It does not require treatment.

  • Outcome

    It is estimated that de novo (primary) dysplasia progresses to bladder...

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References and Further Reading

  • Epstein, J. I., Reuter, V. E., & Amin, M. B. (2010). Biopsy interpreatation of the bladder (2nd ed.). Philadelphia: Wolters Kluwer.

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  • Hartmann, A., Schlake, G., Zaak, D., et al. (2002). Occurrence of chromosome 9 and p53 alterations in multifocal dysplasa and carcinoma in situ of human urinary bladder. Cancer Research, 62, 809–818.

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  • Jung, S., Wu, C., Eslami, Z., et al. (2014). The role of immunohistochemistry in the diagnosis of flat urothelial lesions: A study using CK20, CK5/6, P53, CD138 AND Her2/neu. Annals of Diagnostic Pathology, 18, 27–32.

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  • Lopez-Beltran, A., Alvarez-Kindelan, J., Luque, R. J., et al. (2008). Loss of heterozygosity at 9q32-33 (DBC1 locus) in primary non-invasive papillary urothelial neoplasm of low maòignant potential and low-grade urothelial carcinoma of the bladder and their associated normal urothelium. The Journal of Pathology, 215, 263–272.

    Article  CAS  Google Scholar 

  • Lopez-Beltran, A., Montironi, R., & Cheng, L. (2016). Pathology of the urinary bladder. An algorithmic approach. Cambridge: Cambridge University Press.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Histopathology and Molecular Diagnostics, University Hospital Careggi, Florence, Italy

    Maria Rosaria Raspollini

  2. Pathology Service, Champalimaud Clinical Center, Lisbon, Portugal

    Antonio Lopez-Beltran

  3. Unit of Anatomic Pathology, Department of Surgery, Cordoba University Medical School, Cordoba, Spain

    Antonio Lopez-Beltran

Authors
  1. Maria Rosaria Raspollini
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  2. Antonio Lopez-Beltran
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Corresponding author

Correspondence to Maria Rosaria Raspollini .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Cite this entry

Raspollini, M.R., Lopez-Beltran, A. (2019). Urothelial Dysplasia. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4992-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4992-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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