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Urinary Tract Pure Squamous Cell Carcinoma

  • Living reference work entry
  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 27 Accesses

Synonyms

Squamous cell carcinoma (SCC)

Definition

Malignant neoplasm arising from the urothelium that shows a pure squamous phenotype.

Pure squamous cell carcinoma may occur de novo or in parasite Schistosoma haematobium-infected individuals. The two entities are characterized by different epidemiology and natural history, and they will be discussed separately.

Urinary Tract Pure Squamous Cell Carcinoma Unrelated to Schistosomiasis

Clinical Features

  • Incidence

    It represents 3% to 6% of bladder malignancies (Lagwinski et al. 2007). The patients have a history of chronic bladder irritation caused by infection, stones, indwelling catheters, urinary retention, or neurogenic bladder.

  • Age

    These tumors are most often diagnosed during the seventh decade of life.

  • Sex

    The incidence of SCC shows lower male predominance than urothelial carcinoma, with a male to female ratio of 1.4:1 (Johansson and Cohen 1997). There is higher incidence in women relative to men for stage T3–T4 tumors (Ploeg et al. 2010...

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References and Further Reading

  • Botella, E., Borgues, O., Navarro, S., et al. (2000). Warty carcinoma arising in a condyloma acuminatum of the bladder: a case report. International Journal of Surgical Pathology, 8, 253–259.

    Article  PubMed  Google Scholar 

  • Holck, S., & Jorgensen, L. (1983). Verrucous carcinoma of the bladder. Urology, 22, 435–437.

    Article  CAS  PubMed  Google Scholar 

  • Johansson, S. L., & Cohen, S. M. (1997). Epidemiology and etiology of bladder cancer. Seminars in Surgical Oncology, 13, 291–298.

    Article  CAS  PubMed  Google Scholar 

  • Lagwinski, N., Thomas, A., Stephenson, A. J., et al. (2007). Squamous cell carcinoma of the bladder: a clinicopathological analysis of 45 cases. The American Journal of Surgical Pathology, 31, 1777–1787.

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  • Lopez-Beltran, A., & Escudero, A. L. (1997). Human papillomavirus and bladder cancer. Biomedicine & Pharmacotherapy, 51, 252–257.

    Article  CAS  Google Scholar 

  • Lopez-Beltran, A., Requena, M. J., Alvarez-Kindelan, J., et al. (2007). Squamous differentiation in primary urothelial carcinoma of the urinary tract as seen by MAC387 immunohistochemistry. Journal of Clinical Pathology, 60, 332–335.

    Article  PubMed  Google Scholar 

  • Nishiyama, H., Habuchi, T., Watanabe, J., et al. (2004). Clinical outcome of a large-scale multi-institutional retrospective study for locally advanced bladder cancer: a survey including 1131 patients treated during 1990–2000 in Japan. European Urology, 45, 176–181.

    Article  PubMed  Google Scholar 

  • Patterson, J. M., Ray, E. H., Jr., Mendiondo, O. A., et al. (1988). A new treatment for invasive squamous cell bladder cancer: the Nigro regimen: preoperative chemotherapy and radiation therapy. The Journal of Urology, 140, 379–380.

    Article  CAS  PubMed  Google Scholar 

  • Ploeg, M., Aben, K. K., Hulsbergen-van de Kaa, C. A., et al. (2010). Clinical epidemiology of nonurothelial bladder cancer: analysis of the Netherlands Cancer Registry. The Journal of Urology, 183, 915–920.

    Article  PubMed  Google Scholar 

  • Salem, S., Mitchell, R. E., El-Alim El-Dorey, A., et al. (2011). Successful control of schistosomiasis and the changing epidemiology of bladder cancer in Egypt. BJU International, 107, 206–211.

    Article  PubMed  Google Scholar 

  • Serretta, V., Pomara, G., Piazza, F., & Gange, E. (2000). Pure squamous cell carcinoma of the bladder in western countries. Report on 19 consecutive cases. European Urology, 37, 85–89.

    Article  CAS  PubMed  Google Scholar 

  • Westenend, P. J., Stoop, J. A., & Hendriks, J. G. (2001). Human papillomaviruses 6/11, 16/18 and 31/35/51 are not associated with squamous cell carcinoma of the urinary bladder. BJU International, 88, 198–201.

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Histopathology and Molecular Diagnostics, University Hospital Careggi, Florence, Italy

    Maria Rosaria Raspollini

  2. Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA

    Liang Cheng

  3. Pathology Service, Champalimaud Clinical Center, Lisbon, Portugal

    Antonio Lopez-Beltran

  4. Unit of Anatomic Pathology, Department of Surgery, Cordoba University Medical School, Cordoba, Spain

    Antonio Lopez-Beltran

Authors
  1. Maria Rosaria Raspollini
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  2. Liang Cheng
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  3. Antonio Lopez-Beltran
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Corresponding author

Correspondence to Maria Rosaria Raspollini .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Raspollini, M.R., Cheng, L., Lopez-Beltran, A. (2019). Urinary Tract Pure Squamous Cell Carcinoma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4973-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4973-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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