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Teratoma with Somatic-Type Malignancy

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Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

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Synonyms

Teratoma with a secondary malignant component; Teratoma with malignant transformation (not recommended)

Definition

Teratoma with a distinct secondary component that resembles a somatic-type malignant neoplasm.

Clinical Features

Teratoma with somatic-type malignancy (TSM) occurs in 3–6% of testicular germ cells tumors (Colecchia et al. 2011) only in postpubertal patients (range 15–68 years). The majority of the cases occur together with teratomatous GCTs, and only occasionally in a non-teratomatous germ cell tumor (i.e., yolk sac tumor) or in a spermatocytic tumor. If in a somatic-type malignancy arising within a teratoma the tumor is limited to the testis, the prognosis is not negatively affected. In metastatic sites, somatic-type malignancies have a dismal prognosis. A stage-specific survival of 100% for patients with stage I tumors, 87.5% for stage II, and 53% for stage III has been reported (Colecchia et al. 2011). Patients usually respond poorly to the cisplatin-based...

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References and Further Reading

  • Colecchia, M., Necchi, A., Paolini, B., Nicolai, N., & Salvioni, R. (2011). Teratoma with somatic-type malignant components in germ cell tumors of the testis: A clinicopathologic analysis of 40 cases with outcome correlation. International Journal of Surgical Pathology, 19(3), 321–327.

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  • Giannatempo, P., Pond, G. R., Sonpavde, G., Albany, C., Loriot, Y., Sweeney, C. J., Salvioni, R., Colecchia, M., Nicolai, N., Raggi, D., Rice, K. R., Flack, C. K., El Mouallem, N. R., Feldman, H., Fizazi, K., Einhorn, L. H., Foster, R. S., Necchi, A., & Cary, C. (2016). Treatment and clinical outcomes of patients with teratoma with somatic-type malignant transformation: An international collaboration. Journal of Urology, 196(1), 95–100.

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  • Guo, C. C., Punar, M., Contreras, A. L., Tu, S. M., Pisters, L., Tamboli, P., & Czerniak, B. (2009). Testicular germ cell tumors with sarcomatous components: An analysis of 33 cases. The American Journal of Surgical Pathology, 33(8), 1173–1178.

    Article  Google Scholar 

  • Ulbright, T. M., Hattab, E. M., Zhang, S., Ehrlich, Y., Foster, R. S., Einhorn, L. H., & Cheng, L. (2010). Primitive neuroectodermal tumors in patients with testicular germ cell tumors usually resemble pediatric-type central nervous system embryonal neoplasms and lack chromosome 22 rearrangements. Modern Pathology, 23(7), 972–980.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Uropathology Unit, Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy

    Maurizio Colecchia

  2. Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy

    Alessia Bertolotti

Authors
  1. Maurizio Colecchia
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  2. Alessia Bertolotti
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Corresponding author

Correspondence to Maurizio Colecchia .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Colecchia, M., Bertolotti, A. (2019). Teratoma with Somatic-Type Malignancy. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4955-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4955-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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