Skip to main content
SpringerLink
Log in

Prostatic Neuroendocrine Tumors

  • Living reference work entry
  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 49 Accesses

Synonyms

Carcinoid tumor: Synonym for well-differentiated neuroendocrine tumor (Fine 2018; Wang and Epstein 2008)

Definition

Prostate cancers with neuroendocrine differentiation include:

  • Usual adenocarcinoma with neuroendocrine differentiation

  • Adenocarcinoma with Paneth cell-like neuroendocrine differentiation

  • Well-differentiated neuroendocrine tumor (carcinoid tumor)

  • Small cell neuroendocrine carcinoma

  • Large cell neuroendocrine carcinoma

Clinical Features

  • Incidence

    Depending on the type of prostatic neuroendocrine tumors; 0.5–1% of men with prostate cancer. Autopsy studies of men who have died of castration-resistant prostate cancer (CRPC) have reported the presence of SCC in up to 10–20% of cases (Turbat-Herrera et al. 1988).

  • Age

    Adults

  • Sex

    Male

  • Site

    All prostate zones

  • Treatment

    Surgery and/or chemotherapy as with neuroendocrine tumors of other organs

  • Outcome

    Neuroendocrine tumors can be aggressive, similar to these in other organs. Large cell neuroendocrine carcinoma shows poor...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References and Further Reading

  • Fine, S. W. (2018). Neuroendocrine tumors of the prostate. Modern Pathology, 31(S1), S122–S132.

    Article  Google Scholar 

  • Miyoshi, Y., et al. (2001). Neuroendocrine differentiated small cell carcinoma presenting as recurrent prostate cancer after androgen deprivation therapy. BJU International, 88, 982–983.

    Article  CAS  Google Scholar 

  • Tanaka, M., et al. (2001). Progression of prostate cancer to neuroendocrine cell tumour. International Journal of Urology, 8, 431–437.

    Article  CAS  Google Scholar 

  • Turbat-Herrera, E. A., et al. (1988). Neuroendocrine differentiation in prostatic carcinomas. A retrospective autopsy study. Archives of Pathology & Laboratory Medicine, 112, 1100–1105.

    CAS  Google Scholar 

  • Wang, W., & Epstein, J. I. (2008). Small cell carcinoma of the prostate. A morphologic and immunohistochemical study of 95 cases. The American Journal of Surgical Pathology, 32(1), 65–71.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region (Ancona), Ancona, Italy

    Alessia Cimadamore & Rodolfo Montironi

  2. Department of Pathology and Surgery, Faculty of Medicine, University of Cordoba Medical School, Cordoba, Spain

    Antonio Lopez-Beltran

Authors
  1. Alessia Cimadamore
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Antonio Lopez-Beltran
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rodolfo Montironi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Rodolfo Montironi .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Cimadamore, A., Lopez-Beltran, A., Montironi, R. (2019). Prostatic Neuroendocrine Tumors. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4916-1

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4916-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation