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Prostatic Basal Cell Carcinoma

  • Living reference work entry
  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 40 Accesses

Synonyms

Adenoid cystic carcinoma

Definition

A malignant neoplasm composed of prostatic basal cells (Ali and Epstein 2007; Ahuja et al. 2011; Iczkowski et al. 2003).

Clinical Features

  • Incidence

    Rare.

  • Age

    Mean patient age is 66–69 years.

  • Sex

    Male.

  • Site

    Transition zone of the prostate.

  • Treatment

    It requires ablative therapy with more aggressive behavior seen with the solid nested pattern.

  • Outcome

    These tumors predominantly show an indolent course with local infiltrative behavior. A small subset behaves aggressively with local recurrences and distant metastases. This group is characterized by large solid nests, more often with central necrosis, high Ki67%, and patchy staining with basal cell markers.

Microscopy

Most cases show varying proportions of: adenoid cystic/cribriform pattern with inspissated secretions and basaloid pattern with small solid nests with peripheral palisading of basal cells.

Other patterns included: basal cell hyperplasia-like, small tubules occasionally lined by a...

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References and Further Reading

  • Ahuja, A., Das, P., Kumar, N., Saini, A. K., Seth, A., & Ray, R. (2011). Adenoid cystic carcinoma of the prostate: Case report on a rare entity and review of the literature. Pathology, Research and Practice, 207, 391–394.

    Article  Google Scholar 

  • Ali, T. Z., & Epstein, J. I. (2007). Basal cell carcinoma of the prostate: A clinicopathologic study of 29 cases. The American Journal of Surgical Pathology, 31, 697–705.

    Article  Google Scholar 

  • Bishop, J. A., Yonescu, R., Epstein, J. I., & Westra, W. H. (2015). A subset of prostatic basal cell carcinomas harbor the MYB rearrangement of adenoid cystic carcinoma. Human Pathology, 46(8), 1204–1208.

    Article  CAS  Google Scholar 

  • Iczkowski, K. A., & Montironi, R. (2006). Adenoid cystic/basal cell carcinoma of the prostate strongly expresses HER-2/neu. Journal of Clinical Pathology, 59, 1327–1330.

    Article  CAS  Google Scholar 

  • Iczkowski, K. A., Ferguson, K. L., Grier, D. D., Hossain, D., Banerjee, S. S., McNeal, J. E., & Bostwick, D. G. (2003). Adenoid cystic carcinoma of the prostate: Clinicopathologic findings in 19 cases. The American Journal of Surgical Pathology, 27, 1523–1529.

    Article  Google Scholar 

  • Yang, X. J., McEntee, M., & Epstein, J. I. (1998). Distinction of basaloid carcinoma of the prostate from benign basal cell lesions by using immunohistochemistry for bcl-2 and Ki67. Human Pathology, 29, 1447–1450.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region (Ancona), Ancona, Italy

    Alessia Cimadamore & Rodolfo Montironi

  2. Indiana University School of Medicine, Department of Pathology and Laboratory Medicine, Indianapolis, IN, USA

    Liang Cheng

Authors
  1. Alessia Cimadamore
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  2. Liang Cheng
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  3. Rodolfo Montironi
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Corresponding author

Correspondence to Rodolfo Montironi .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Cite this entry

Cimadamore, A., Cheng, L., Montironi, R. (2019). Prostatic Basal Cell Carcinoma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4910-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4910-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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