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Prostatic Acinar Adenocarcinoma, Mucinous Variant

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  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 36 Accesses

Synonyms

Colloid (adeno)carcinoma

Definition

Mucinous adenocarcinoma is defined as a tumor composed by large pools of extracellular mucin that must comprise at least 25% of the tumor volume (Bohman and Osunkoya 2012; Moch et al. 2016; Osunkoya and Epstein 2007).

Clinical Features

  • Incidence

    Approximately 0.2% of prostatic adenocarcinomas are diagnosed as mucinous adenocarcinoma.

  • Age

    Patients present at mean age of 56 (range 44–69) with an elevated serum PSA (mean 9 ng/ml).

  • Sex

    Male.

  • Site

    Peripheral and transition zones of the prostate.

  • Treatment

    Similar to those of usual acinar adenocarcinoma.

  • Outcome

    Mucinous adenocarcinoma has a survival similar to that of usual adenocarcinoma (Bohman and Osunkoya 2012; Osunkoya et al. 2008).

Macroscopy

The cut surface of the prostate gland can have a mucinous or gelatinous appearance when the extracellular mucin constitutes a large portion of the tumor (Fig. 1).

Fig. 1
figure 1

Whole amount section of prostate gland with mucinous adenocarcinoma

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References and Further Reading

  • Bohman, K. D., & Osunkoya, A. O. (2012). Mucin-producing tumors and tumor-like lesions involving the prostate: A comprehensive review. Advances in Anatomic Pathology, 19, 374–387.

    Article  CAS  Google Scholar 

  • Han, B., Mehra, R., Suleman, K., et al. (2009). Characterization of ETS gene aberrations in select histologic variants of prostate carcinoma. Modern Pathology, 22(9), 1176–1185.

    Article  CAS  Google Scholar 

  • Moch, H., Humphrey, P. A., & Ulbright, T. M. (Eds.). (2016). WHO classification of tumours of the urinary system and male genital organs (4th ed., pp. 138–161). Lyon: International Agency for Research on Cancer.

    Google Scholar 

  • Osunkoya, A. O. (2018). Mucinous and secondary tumors of the prostate. Modern Pathology, 31(S1), S80–S95.

    Article  Google Scholar 

  • Osunkoya, A. O., & Epstein, J. I. (2007). Primary mucin-producing urothelial-type adenocarcinoma of prostate: Report of 15 cases. American Journal of Surgical Pathology, 31, 1323–1329.

    Article  Google Scholar 

  • Osunkoya, A. O., Nielsen, M. E., & Epstein, J. I. (2008). Prognosis of mucinous adenocarcinoma of the prostate treated by radical prostatectomy: A study of 47 cases. American Journal of Surgical Pathology, 32, 468–472.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region (Ancona), Ancona, Italy

    Alessia Cimadamore & Rodolfo Montironi

  2. Department of Pathology and Surgery, Faculty of Medicine, Cordoba, Spain

    Antonio Lopez-Beltran

Authors
  1. Alessia Cimadamore
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  2. Antonio Lopez-Beltran
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  3. Rodolfo Montironi
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Corresponding author

Correspondence to Rodolfo Montironi .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Cimadamore, A., Lopez-Beltran, A., Montironi, R. (2019). Prostatic Acinar Adenocarcinoma, Mucinous Variant. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4905-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4905-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

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