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Encyclopedia of Pathology pp 1–2Cite as

Prostatic Acinar Adenocarcinoma, Foamy Gland Variant

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Part of the book series: Encyclopedia of Pathology ((EP))

Definition

Adenocarcinoma characterized by abundant foamy or xanthomatous-type cytoplasm with pyknotic nuclei (Hudson et al. 2012; Warrick and Humphrey 2013).

Clinical Features

  • Incidence

    It is typically found as a component of acinar carcinoma (in 16–22% of cases) and is only rarely pure (in 0.2–2% of cases)

  • Age

    Mainly among patients aged 60–70 years.

  • Sex

    Male.

  • Site

    Mainly peripheral zone of the prostate.

  • Treatment

    Similar to those of usual acinar adenocarcinoma.

  • Outcome

    Similar to those of usual acinar adenocarcinoma: The presence of prostatic adenocarcinoma with foamy glands is not likely to be of prognostic significance (Hudson et al. 2012; Nelson and Epstein 1996; Tran et al. 2001).

Macroscopy

Similar to those of usual acinar adenocarcinoma. There are no reported gross descriptions of prostatic adenocarcinoma with foamy glands.

Microscopy

Foamy gland adenocarcinoma is characterized by abundant foamy or xanthomatous type cytoplasm with small hyperchromatic nuclei, and minimal or no...

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References and Further Reading

  • Hudson, J., Cao, D., Vollmer, R., et al. (2012). Foamy gland carcinoma of the prostate: Incidence, Gleason grade, and early clinical outcome. Human Pathology, 43, 974–979.

    Article  Google Scholar 

  • Humphrey, P. A. (2018). Variants of acinar adenocarcinoma of the prostate mimicking benign conditions. Modern Pathology, 31(S1), S64–S70.

    Article  Google Scholar 

  • Koca, S. B., Yildiz, P., & Behzatoglu, K. (2014). Foamy gland carcinoma in core needle biopsies of the prostate: Clinicopathologic and immunohistochemical study of 56 cases. Annals of Diagnostic Pathology, 18, 271–274.

    Article  Google Scholar 

  • Nelson, R. S., & Epstein, J. I. (1996). Prostatic carcinoma with abundant xanthomatous cytoplasm. Foamy gland carcinoma. American Journal of Surgical Pathology, 20, 419–426.

    Article  CAS  Google Scholar 

  • Tran, T. T., Sengupta, E., & Yang, X. Y. (2001). Prostatic foamy gland carcinoma with aggressive behavior. Histologic, immunohistochemical, and ultrastructural analysis. American Journal of Surgical Pathology, 25, 618–623.

    Article  CAS  Google Scholar 

  • Warrick, J. I., & Humphrey, P. A. (2013). Foamy gland carcinoma of the prostate in needle biopsy: Incidence, Gleason grade, and comparative alpha-methylacyl-CoA racemase versus ERG expression. American Journal of Surgical Pathology, 37, 1709–1714.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region (Ancona), Ancona, Italy

    Alessia Cimadamore & Rodolfo Montironi

  2. Histopathology and Molecular Diagnostics, University Hospital Careggi, Florence, Italy

    Maria Rosaria Raspollini

Authors
  1. Alessia Cimadamore
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  2. Maria Rosaria Raspollini
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  3. Rodolfo Montironi
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Corresponding author

Correspondence to Rodolfo Montironi .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Cite this entry

Cimadamore, A., Raspollini, M.R., Montironi, R. (2019). Prostatic Acinar Adenocarcinoma, Foamy Gland Variant. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4903-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4903-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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