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Peyronie’s Disease

  • Living reference work entry
  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

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Definition

It is a condition characterized by focal replacement of the subcutaneous tissue of the penile shaft by a dense fibrous band connecting the tunica albuginea with the corpus cavernosum.

Clinical Features

  • Incidence

    It occurs in less than 25 males per 100,000 subjects (Lindsay et al. 1991).

  • Age

    The mean age of presentation shows a wide range, affecting men in the 3rd to 7th decade.

  • Sex

    Male.

  • Site

    The occurrence of a curvature in the erect penis, the curvature bending toward a fibrous plaque of variable size localized in the shaft is the typical occurrence. Painful, abnormal curvature of the penis or hard penile swelling is typical presentations.

  • Outcome

    Malignant degeneration has not been reported.

Macroscopy

A palpable plaque on the penile shaft could be present as single or multiple nodules with partial calcifications.

Microscopy

It consists of dense poorly cellular connective tissue containing occasional fibroblasts, resembling fibromatosis. Perivascular inflammation occurs...

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References and Further Reading

  • Gelbard, M. K. (1988). Dystrophic penile calcification in Peyronie’s disease. Journal of Urology, 139(4), 738–740.

    Article  CAS  Google Scholar 

  • Leopardi, O., Colombo, F., Frigo, B., Zucchi, A., Patelli, E., Colecchia, M., Mantovani, F., Naughten, W., & Pisani, E. (2000). Immunohistochemical and quantitative study of mast cells in La Peyronie’s disease. European Urology, 37(2), 176–182.

    Article  CAS  Google Scholar 

  • Lindsay, M. B., Schain, D. M., Grambsch, P., Benson, R. C., Beard, C. M., & Kurland, L. T. (1991). The incidence of Peyronie’s disease in Rochester, Minnesota, 1950 through 1984. Journal of Urology, 146(4), 1007–1009.

    Article  CAS  Google Scholar 

  • Usta, M. F., Adams, D. M., Zhang, J. W., Davis, R., & Hellstrom, W. J. (2003). Penile epithelioid sarcoma and the case for a histopathological diagnosis in Peyronie’s disease. British Journal of Urology, 91(6), 519–521.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Uropathology Unit, Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy

    Maurizio Colecchia

  2. Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy

    Alessia Bertolotti

Authors
  1. Maurizio Colecchia
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  2. Alessia Bertolotti
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Corresponding author

Correspondence to Maurizio Colecchia .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Colecchia, M., Bertolotti, A. (2019). Peyronie’s Disease. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4896-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4896-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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