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Penile Squamous Cell Carcinoma, Usual Type

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  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

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Synonyms

Epidermoid carcinoma; Squamous cell carcinoma not otherwise specified (NOS)

Definition

Invasive epithelial neoplasm with variable degrees of squamous differentiation and keratinization, diagnosed after the exclusion of other histological variants. Lack of keratinization is sufficient for exclusion from this category.

Clinical Features

  • Incidence: Usual-type squamous cell carcinoma (USCC) is the most frequent penile tumor, occurring in almost 50% of cases. The different rates among countries and regional differences in prevalence even in the same country are not fully understood (Chaux et al. 2010). Several risk factors have been associated with the development of this cancer, including phimosis, smoking or chewing tobacco, chronic inflammation, tears, abrasions, balanitis, injuries to the penis, and poor hygiene and association of warm climate with poverty.

  • Age: It presents most frequently in the 6th to 7th decades of life.

  • Sex: Male.

  • Site: Typically tumors of the glans spread...

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References and Further Reading

  • Chaux, A., Lezcano, C., Cubilla, A. L., Tamboli, P., Ro, J., & Ayala, A. (2010). Comparison of subtypes of penile squamous cell carcinoma from high and low incidence geographical regions. International Journal of Surgical Pathology, 18(4), 268–277.

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  • Chaux, A., Amin, M., Cubilla, A. L., & Young, R. H. (2011). Metastatic tumors to the penis: A report of 17 cases and review of the literature. International Journal of Surgical Pathology, 19(5), 597–606.

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  • Chaux, A., Han, J. S., Lee, S., Gonzalez-Roibon, N., Sharma, R., Burnett, A. L., Cubilla, A. L., & Netto, G. J. (2013). Immunohistochemical profile of the penile urethra and differential expression of GATA3 in urothelial versus squamous cell carcinomas of the penile urethra. Human Pathology, 44(12), 2760–2767.

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  • Guimaraes, G. C., Cunha, I. W., Soares, F. A., Lopes, A., Torres, J., Chaux, A., Velazquez, E. F., Ayala, G., & Cubilla, A. L. (2009). Penile squamous cell carcinoma clinicopathological features, nodal metastasis and outcome in 333 cases. The Journal of Urology, 182(2), 528–534.

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Author information

Authors and Affiliations

  1. Uropathology Unit, Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milan, Milan, Italy

    Maurizio Colecchia

  2. Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy

    Alessia Bertolotti

Authors
  1. Maurizio Colecchia
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  2. Alessia Bertolotti
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Corresponding author

Correspondence to Maurizio Colecchia .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Colecchia, M., Bertolotti, A. (2019). Penile Squamous Cell Carcinoma, Usual Type. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4890-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4890-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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