Synonyms
Definition
PUNLMP is defined by the 2004/2016 WHO classification system as a papillary urothelial tumor with increased cellular proliferation, exceeding the thickness of normal urothelium, without atypia (Johansson and Busch 2004; Reuter et al. 2016). These tumors had been classified as grade 1 urothelial carcinoma by the WHO 1973 grading system (Mostofi and Sobin 1973).
Clinical Features
Incidence
PUNLMP has an incidence of 3 cases per 100,000 individuals per year (Reuter et al. 2016).
Age
Mean age at diagnosis is of 64.6 years, range 29–94 (Holmang et al. 1999).
Sex
Male/female ratio is 5:1.
Site
The most frequent sites are lateral and posterior walls close to the ureteric orifices (Johansson and Busch 2004).
Treatment
The most clinical sign is microscopic hematuria, but usually the cytology is negative. Transurethral resection allows a diagnosis. Inter-observer reproducibility in diagnosis of PUNLMP is low, and therefore, it remains a controversial category whose...
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References and Further Reading
Barbisan, F., Santinelli, A., Mazzucchelli, R., et al. (2008). Strong immunohistochemical expression of fibroblast growth factor receptor 3, superficial staining pattern of cytokeratin 20, and low proliferative activity define those papillary urothelial neoplasms of low malignant potential that do not recur. Cancer, 112, 636–644.
Cheng, L., Montironi, R., & Lopez-Beltran, A. (2017). TERT promoter mutations occur frequently in urothelial papilloma and papillary urothelial neoplasm of low malignant potential. European Urology, 71, 497–498.
Holmang, S., Hedelin, H., sl, A., et al. (1999). Recurrence and progression in low grade papillary urothelial tumors. The Journal of Urology, 162, 702–707.
Johansson, S. L., & Busch, C. (2004). Papillary urothelial neoplasm of low malignant potential. In J. N. Eble, G. Sauter, J. I. Epstein, & I. A. Sesterhenn (Eds.), WHO classification of tumours of the urinary system and male genital organs (pp. 115–116). Lyon: IARC.
Mostofi, F., & Sobin, L. (1973). Histologic typing of urinary bladder tumors. Geneva: World Health Organization.
Reuter, V. E., Algaba, F., Amin, M. B., Cao, D., Cheng, L., et al. (2016). Non-invasive urothelial lesions. In H. Moch, P. A. Humphrey, T. M. Ulbright, & V. E. Reuter (Eds.), WHO classification of tumours of the urinary system and male genital organs (pp. 99–107). Lyon: IARC.
Wang, C.-C., Huang, C.-Y., Jhuang, Y.-L., et al. (2018). Biological significance of TERT promoter mutation in papillary urothelial neoplasm of low malignant potential. Histopathology, 72, 795–803.
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Henriques, V., Raspollini, M.R., Lopez-Beltran, A. (2019). Papillary Urothelial Neoplasm of Low Malignant Potential. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4872-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_4872-1
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