Synonyms
Definition
Malignant tumor with variable degree of osteoid production by neoplastic cells.
Clinical Features
Incidence
Osteosarcoma is a rare neoplasm, representing about 0.2% of all malignant tumors. The estimated incidence is of three cases/million population/year.
Age
The peak of incidence is between 10 and 25 years of age, while is rare before age 5. Adults over 50 years could be also affected, in particular, in association with risk factors (e.g., post-radiation or Paget disease of bone).
Sex
Males are affected more frequently than females (male: female ratio 1.4:1).
Site
The tumor is usually located in the metaphysis of long bones (distal femur, proximal tibia, and proximal humerus). It is occasionally seen in diaphysis (<9%) and, rarely, in epiphyseal region. It is less common in flat or short bones. In male genital organs, cases of osteosarcoma have been rarely observed. In the English literature, there are reports of five cases of testicular primary...
References and Further Reading
Al-Masri, A., Al-Shraim, M., Al-Samen, A. A., Chetty, R., & Evans, A. (2007). Primary paratesticular osteosarcoma: Case report and a review of the literature. TSW Urology, 2, 124–128.
Beiswanger, J. C., Woodruff, R. D., Savane, P. D., & Assimos, D. G. (1997). Primary osteosarcoma of the spermatic cord with synchronous bilateral renal cell carcinoma. Urology, 49, 957–959.
Hong, R., Lee, G., Kim, H., Kim, C. S., & Kee, K. H. (2011). Primary paratesticular osteosarcoma: A case report. Oncology Letters, 3(3), 554–556.
Spirtos, G., Abdu, R. A., & Schaub, C. R. (1991). Osteosarcoma of the spermatic cord. The Journal of Urology, 145, 832–833.
Tazi, H., Karmouni, T., Ouali, M., et al. (2006). Osteosarcoma of the testis. International Journal of Urology, 13, 323–324.
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Gaeta, R., Franchi, A. (2019). Osteosarcoma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4866-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_4866-1
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