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Inflammatory Myofibroblastic Tumor

  • Living reference work entry
  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 51 Accesses

Synonyms

Inflammatory myofibrohistiocytic proliferation; Inflammatory pseudotumor; Plasma cell granuloma; Pseudosarcomatous myofibroblastic tumor

Definition

Inflammatory myofibroblastic tumor (IMT) is a tumor composed of myofibroblasts accompanied by a mixed inflammatory infiltrate.

Clinical Features

  • Incidence

    IMT is a relatively rare tumor in the genitourinary system.

  • Age

    It may occur at all ages, including in children. The mean age at diagnosis is 50 years.

  • Sex

    It involves more frequently male subjects.

  • Site

    Genitourinary IMT arise more frequently in the bladder, but cases have been reported also in the kidneys, prostate, spermatic cord, and testis.

  • Treatment

    In the bladder, most cases are treated with transurethral resection. Some patients have undergone partial cystectomy.

  • Outcome

    IMT is a locally aggressive neoplasm, with tendency to local recurrence, and rare incidence of metastasis.

Macroscopy

Grossly, IMT appears as a circumscribed solitary or multinodular mass with a white to...

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References and Further Reading

  • Harik, L. R., Merino, C., Coindre, J. M., et al. (2006). Pseudosarcomatous myofibroblastic proliferations of the bladder: A clinicopathologic study of 42 cases. The American Journal of Surgical Pathology, 30, 787–794.

    Article  Google Scholar 

  • Jebastin, J. A. S., Smith, S. C., Perry, K. D., Gupta, N. S., Alanee, S., Carskadon, S., Chitale, D. A., Palanisamy, N., & Williamson, S. R. (2018). Pseudosarcomatous myofibroblastic proliferations of the genitourinary tract are genetically different from nodular fasciitis and lack USP6, ROS1 and ETV6 gene rearrangements. Histopathology, 73, 321–326.

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  • Kapusta, L., Weiss, M., Ramsay, J., et al. (2003). Inflammatory myofibroblastic tumors of the kidney: A clinicopathologic and immunohistochemical study of 12 cases. The American Journal of Surgical Pathology, 27, 658–666.

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  • Montgomery, E. A., Shuster, D. D., Burkart, A. L., Esteban, J. M., Sgrignoli, A., Elwood, L., Vaughn, D. J., Griffin, C. A., & Epstein, J. I. (2006). Inflammatory myofibroblastic tumors of the urinary tract: A clinicopathologic study of 46 cases, including a malignant example inflammatory fibrosarcoma and a subset associated with high-grade urothelial carcinoma. The American Journal of Surgical Pathology, 30, 1502–1512.

    Article  Google Scholar 

  • Tsuzuki, T., Magi-Galluzzi, C., & Epstein, J. I. (2004). ALK-1 expression in inflammatory myofibroblastic tumor of the urinary bladder. The American Journal of Surgical Pathology, 28, 1609–1614.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Translational Research and of New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy

    Alessandro Franchi

Authors
  1. Alessandro Franchi
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Corresponding author

Correspondence to Alessandro Franchi .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Franchi, A. (2019). Inflammatory Myofibroblastic Tumor. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4832-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4832-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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