Synonyms
Definition
Inflammation of periurethral glands of Littre (tubule-acinar mucinous glands located along the urethra that secrete mucus and are most numerous in the section of the urethra that runs through the penis).
Clinical Features
Incidence
Very rare
Age
Young adults mainly
Sex
Male
Site and Presentation
Patients usually report pain or discomfort during urination and urinalysis highlights an increase of leukocytes. Sometimes it presents with a firm small nodule of the penis or urethra (Krawitt and Schechterman 1977).
Treatment
The therapy is symptomatic. If the inflammation process appears as a nodule, excision of the lesion is required due to the differential diagnosis with neoplastic masses.
Outcome
Excellent prognosis
Macroscopy
The nodular presentation is more relevant in pathology practice and appears as a small tan nodule. The cut surface displays a honeycomb pattern.
Microscopy
The Littre’s gland lumen is occupied with mucus and...
References and Further Reading
Goldblum, J., Lamps, L., McKenney, J., & Myers, J. (2017). Rosai and Ackerman’s surgical pathology (11th ed.). Philadelphia: Elsevier.
Krawitt, L. N., & Schechterman, L. (1977). Inflammation of the periurethral glands of Littre simulating tumor. The Journal of Urology, 118, 685.
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Fattorini, C., Lopez-Beltran, A., Raspollini, M.R. (2019). Inflammation of Littre’s Glands. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4831-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_4831-1
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