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Inflammation of Littre’s Glands

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Encyclopedia of Pathology

Synonyms

Periurethral gland inflammation

Definition

Inflammation of periurethral glands of Littre (tubule-acinar mucinous glands located along the urethra that secrete mucus and are most numerous in the section of the urethra that runs through the penis).

Clinical Features

  • Incidence

    Very rare

  • Age

    Young adults mainly

  • Sex

    Male

  • Site and Presentation

    Patients usually report pain or discomfort during urination and urinalysis highlights an increase of leukocytes. Sometimes it presents with a firm small nodule of the penis or urethra (Krawitt and Schechterman 1977).

  • Treatment

    The therapy is symptomatic. If the inflammation process appears as a nodule, excision of the lesion is required due to the differential diagnosis with neoplastic masses.

  • Outcome

    Excellent prognosis

Macroscopy

The nodular presentation is more relevant in pathology practice and appears as a small tan nodule. The cut surface displays a honeycomb pattern.

Microscopy

The Littre’s gland lumen is occupied with mucus and...

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References and Further Reading

  • Goldblum, J., Lamps, L., McKenney, J., & Myers, J. (2017). Rosai and Ackerman’s surgical pathology (11th ed.). Philadelphia: Elsevier.

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  • Krawitt, L. N., & Schechterman, L. (1977). Inflammation of the periurethral glands of Littre simulating tumor. The Journal of Urology, 118, 685.

    Article  CAS  Google Scholar 

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Correspondence to Maria Rosaria Raspollini .

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Fattorini, C., Lopez-Beltran, A., Raspollini, M.R. (2019). Inflammation of Littre’s Glands. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4831-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4831-1

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  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

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