Inflammation of Littre’s Glands
Inflammation of periurethral glands of Littre (tubule-acinar mucinous glands located along the urethra that secrete mucus and are most numerous in the section of the urethra that runs through the penis).
Young adults mainly
Site and Presentation
Patients usually report pain or discomfort during urination and urinalysis highlights an increase of leukocytes. Sometimes it presents with a firm small nodule of the penis or urethra (Krawitt and Schechterman 1977).
The therapy is symptomatic. If the inflammation process appears as a nodule, excision of the lesion is required due to the differential diagnosis with neoplastic masses.
The nodular presentation is more relevant in pathology practice and appears as a small tan nodule. The cut surface displays a honeycomb pattern.
The Littre’s gland lumen is occupied with mucus and inflammatory cells. In the surrounding stroma, there is a dense inflammatory infiltrate composed of neutrophils, lymphocytes, and plasma cells. The stroma also displays collagen deposition and dilated vascular channels.
Inflammation of Littre’s glands may simulate a tumor when present as a nodule (tumorlike condition) (Goldblum et al. 2017). However the histologic appearance is straightforward.
References and Further Reading
- Goldblum, J., Lamps, L., McKenney, J., & Myers, J. (2017). Rosai and Ackerman’s surgical pathology (11th ed.). Philadelphia: Elsevier.Google Scholar