Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Infarct of the Prostate

  • Alessia Cimadamore
  • Marina Scarpelli
  • Rodolfo MontironiEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_4829-1

Synonyms

Definition

Coagulative necrosis of the prostate gland tissue from a lack of blood supply (Milord et al. 2000).

Clinical Features

  • Incidence

    Rare on biopsy: 0.7%

  • Age

    Men averaged 71 years of age (range, 57–84 years).

  • Sex

    Men.

  • Site

    Transition zone of the prostate.

  • Treatment

    No treatment unless with acute urinary retention.

  • Outcome

    None. It might be followed by acute urinary retention. It may result in sudden rises in serum PSA.

Macroscopy

Whitish or yellowish soft areas in the transition zone associated with benign prostatic hyperplasia. The pattern is not specific for infarction.

Microscopy

Coagulative necrosis surrounded by immature squamous cell metaplasia of the surrounding ducts and acini. The epithelium shows regenerative atypia. Necrosis tissue is replaced by dense fibrosis. Ischemic type infarcts show sharply outlined areas of coagulative necrosis of glands and stroma (Milord et al. 2000) (Fig. 1).
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References and Further Reading

  1. Milord, R. A., Kahane, H., & Epstein, J. I. (2000). Infarct of the prostate gland: Experience on needle biopsy specimens. American Journal of Surgical Pathology, 24(10), 1378–1384.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Alessia Cimadamore
    • 1
  • Marina Scarpelli
    • 1
  • Rodolfo Montironi
    • 1
    Email author
  1. 1.Institute of Pathological Anatomy and HistopathologyPolytechnic University of the Marche Region (Ancona)AnconaItaly