Granulosa Cell Tumor

Definition

Granulosa cell tumors of the testis are macro- and microscopically equal to those arising in the ovaries. Because of the different morphologies, two types are distinguished: an adult and a juvenile type.

Adult Type Granulosa Cell Tumor

Clinical Features

Adult type granulosa cell tumor is a rare testicular tumor with only 46 cases reported in a recent review (Schubert et al. 2014). Almost all the ages are affected (median 45 years; range, 12–83 years). The tumors metastasize even 7 years after presentation in more than 10% of the cases.

Macroscopy

The cut surface has a lobulated appearance, firm consistency, and varies from yellow to beige. The tumor diameter ranges from 0.7 to 13 cm.

Microscopy

Many microscopic patterns have been recognized including trabecular, insular, gyriform, macrofollicular, and microfollicular patterns. The cells have scant cytoplasm, and the nuclei are grooved with coffee-bean appearance (Fig. 1) and sometimes are present Call-Exner bodies.

Fig. 1

Adu...