Benign condition characterized by presence of single or multiple calcified nodules.
Children and young adults.
Skin of scrotum, testis, and paratesticular structures.
Scrotum: Single or multiple mobile masses affecting the skin of this region.
Testis: Single palpable mass of varying size near the pole of the organ.
Calcifying nodules are benign lesions and the prognosis after excision is excellent.
Well-circumscribed yellowish nodules, rarely pedunculated (Gi et al. 2008).
Testis: A flattened epithelium covering a core of connective tissue with interspersed fibroblasts, fibrin-like material, and globular deposition of calcium without an inflammatory infiltrate (Nistal and Paniagua 1989).
Calcified material is positive for Von Kossa stain, rarely used and necessary.
Scrotum: The histological examination allows a definitive diagnosis in almost all cases; however, the nodular appearance and the deposition of material in the dermis may be mistaken with the presentation of nodular amyloidosis. In amyloidosis, the homogeneous eosinophilic material is positive for Congo red and negative for Von Kossa stain.
Testis: Radiological studies are not sufficient to distinguish calcifying nodules from malignant testicular lesions while the histological appearance is straightforward.