Skip to main content
SpringerLink
Log in

Amyloidosis in the Genitourinary Tract

  • Living reference work entry
  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 83 Accesses

Definition

It is a chronic disease with extracellular amyloid deposits in the genitourinary organs.

Clinical-Pathological Classification

  • Systemic:

    • Primary: Commonly AL type amyloid typically associated with some lymphoproliferative disorders.

    • Secondary: AA type amyloid, linked to various chronic inflammatory diseases (rheumatoid arthritis, Crohn disease, ankylosing spondylitis, myeloma, and familial Mediterranean fever).

  • Localized: Deposition of AL type amyloid of unknown etiology.

  • Familial: Frequently associated with Transthyretin mutations.

Clinical Features

  • Incidence

    The true incidence of systemic and localized amyloidosis in genitourinary organs is not currently available.

  • Age

    5th–6th decade.

  • Sex

    • Systemic: Men are mainly affected by AL amyloidosis, women by AA amyloidosis.

    • Localized: No sex prevalence.

  • Site

    • Systemic: Kidney most commonly affected (Chitale et al. 2007).

    • Localized: Renal pelvis and lower genitourinary tract, particularly urinary bladder but also urethra (Monge et al.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References and Further Reading

  • Caballero Martínez, M. C., Gomez, M., Angel Cuesta Alcalá J, et al. (2003). Amyloidosis of the seminal vesicles: Clinical and pathological review of 8 cases diagnosed from surgical specimens. Archivos Españoles de Urología, 56, 431.

    PubMed  Google Scholar 

  • Chitale, S., Morsey, M., Peat, D., & Webb, R. (2007). Amyloidosis of lower genitourinary tract: A review. European Urology Supplements, 5, 70–76.

    Google Scholar 

  • Jain, M., Kumari, N., Chhabra, P., & Gupta, R. (2008). Localized amyloidosis of urinary bladder: A diagnostic dilemma. Indian Journal of Pathology & Microbiology, 51, 247–249.

    Article  Google Scholar 

  • Li, Y., Mongan, J., Behr, S. C., et al. (2016). Beyond prostate adenocarcinoma: Expanding the differential diagnosis in prostate pathologic conditions. Radiographics, 36, 1055–1075.

    Article  Google Scholar 

  • Monge, M., Chauveau, D., Cordonnier, C., et al. (2011). Localized amyloidosis of the genitourinary tract: Report of 5 new cases and review of the literature. Medicine, 90, 212–222.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Histopathology and Molecular Diagnostics, University Hospital Careggi, Florence, Italy

    Caterina Fattorini & Maria Rosaria Raspollini

  2. Pathology Service, Champalimaud Clinical Center, Lisbon, Portugal

    Antonio Lopez-Beltran

  3. Unit of Anatomic Pathology, Department of Surgery, Cordoba University Medical School, Cordoba, Spain

    Antonio Lopez-Beltran

Authors
  1. Caterina Fattorini
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Antonio Lopez-Beltran
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Maria Rosaria Raspollini
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Maria Rosaria Raspollini .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Fattorini, C., Lopez-Beltran, A., Raspollini, M.R. (2019). Amyloidosis in the Genitourinary Tract. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4779-1

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4779-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation