Amyloidosis in the Genitourinary Tract
It is a chronic disease with extracellular amyloid deposits in the genitourinary organs.
Primary: Commonly AL type amyloid typically associated with some lymphoproliferative disorders.
Secondary: AA type amyloid, linked to various chronic inflammatory diseases (rheumatoid arthritis, Crohn disease, ankylosing spondylitis, myeloma, and familial Mediterranean fever).
Localized: Deposition of AL type amyloid of unknown etiology.
Familial: Frequently associated with Transthyretin mutations.
The true incidence of systemic and localized amyloidosis in genitourinary organs is not currently available.
Systemic: Men are mainly affected by AL amyloidosis, women by AA amyloidosis.
Localized: No sex prevalence.
Systemic: Kidney most commonly affected (Chitale et al. 2007).
Localized: Renal pelvis and lower genitourinary tract, particularly urinary bladder but also urethra (Monge et al.
References and Further Reading
- Chitale, S., Morsey, M., Peat, D., & Webb, R. (2007). Amyloidosis of lower genitourinary tract: A review. European Urology Supplements, 5, 70–76.Google Scholar