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Encyclopedia of Pathology pp 1–2Cite as

Acquired Cystic Disease-Associated Renal Cell Carcinoma

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Part of the book series: Encyclopedia of Pathology ((EP))

Definition

A renal tumor with variable morphological patterns arising exclusively in end-stage kidneys with acquired cystic disease.

Clinical Features

  • Incidence

    These tumors occur most often, but not always, in patients undergoing long-term hemodialysis with acquired cystic disease and are usually incidental finding detected during their follow-up. Often they are multiple and bilateral. It represents roughly one third of all renal cell neoplasms arising in end-stage renal disease.

  • Age

    It frequently occurs in patients receiving hemodialysis of more than 10 years

  • Sex

    There is no gender predilection.

  • Site

    There is no site predilection.

  • Treatment

    Surgical treatment is recommended.

  • Outcome

    Because of early detection of tumors in patients on periodical follow-up imaging analyses for chronic renal failure, the clinical behavior is usually indolent.

Macroscopy

The tumor is well circumscribed and tan to yellow in color with occasional hemorrhage or necrosis occurring in a background of multiple...

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References and Further Reading

  • Cossu-Rocca, P., Eble, J. N., Zhang, S., Martignoni, G., Brunelli, M., & Cheng, L. (2006). Acquired cystic disease-associated renal tumors: An immunohistochemical and fluorescence in situ hybridization study. Modern Pathology, 19, 780–787.

    Article  CAS  Google Scholar 

  • Kuroda, N., Tamura, M., Hamaguchi, N., Mikami, S., Pan, C. C., Brunelli, M., Martignoni, G., Hes, O., Michal, M., & Lee, G. H. (2011). Acquired cystic disease–associated renal cell carcinoma with sarcomatoid change and rhabdoid features. Annals of Diagnostic Pathology, 15(6), 462–466.

    Article  Google Scholar 

  • Pan, C. C., Chen, Y. J., Chang, L. C., Chang, Y. H., & Ho, D. M. (2009). Immunohistochemical and molecular genetic profiling of acquired cystic disease-associated renal cell carcinoma. Histopathology, 55, 145–153.

    Article  Google Scholar 

  • Tickoo, S. K., deParalta-Venturia, M. N., Harik, L. R., Worcester, H. D., Salama, M. E., Young, A. N., Moch, H., & Amin, M. B. (2006). Spectrum of epithelial neoplasms in end-stage renal disease: An experience from 66 tumor-bearing kidneys with emphasis on histologic patterns distinct from those in sporadic adult renal neoplasia. The American Journal of Surgical Pathology, 30(2), 141–153.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Diagnostic and Public Health, Section of Pathology, University of Verona, Verona, Italy

    Anna Caliò & Guido Martignoni

  2. Department of Pathology, Pederzoli Hospital, Peschiera del Garda, Italy

    Diego Segala & Guido Martignoni

Authors
  1. Anna Caliò
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  2. Diego Segala
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  3. Guido Martignoni
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Corresponding author

Correspondence to Guido Martignoni .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Cite this entry

Caliò, A., Segala, D., Martignoni, G. (2019). Acquired Cystic Disease-Associated Renal Cell Carcinoma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4775-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4775-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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