Definition
Breast implant-associated anaplastic large cell lymphoma (BI-ALCL) is a very rare form of T-cell lymphoma that arises in association with various kinds of breast implants. In the recently revised WHO classification of hematological malignancies, BI-ALCL is introduced as a new provisional disease entity, distinct from the other types of ALCLs already recognized (Oishi 2018). While the morphological and immunophenotypical features of BI-ALCL are indistinguishable from those of systemic ALK-negative ALCL, the specificity of the newly described entity is its clinical presentation in association with and the vicinity of a breast implant.
Clinical Features
Incidence
A nationwide study based on the pathology registry in the Netherlands established that BI are associated with a markedly increased risk (400 times) of developing ALCL, but the absolute risk remains very small, estimated to one case for every...
This is a preview of subscription content, log in via an institution.
References and Further Reading
Clemens, M. W., Medeiros, L. J., Butler, C. E., Hunt, K. K., Fanale, M. A., Horwitz, S., Weisenburger, D. D., Liu, J., Morgan, E. A., Kanagal-Shamanna, R., Parkash, V., Ning, J., Sohani, A. R., Ferry, J. A., Mehta-Shah, N., Dogan, A., Liu, H., Thormann, N., Di Napoli, A., Lade, S., Piccolini, J., Reyes, R., Williams, T., McCarthy, C. M., Hanson, S. E., Nastoupil, L. J., Gaur, R., Oki, Y., Young, K. H., & Miranda, R. N. (2016). Complete surgical excision is essential for the management of patients with breast implant-associated anaplastic large-cell lymphoma. Journal of Clinical Oncology, 34(2), 160–168.
Ferrufino-Schmidt, M. C., Medeiros, L. J., Liu, H., Clemens, M. W., Hunt, K. K., Laurent, C., Lofts, J., Amin, M. B., Ming Chai, S., Morine, A., Di Napoli, A., Dogan, A., Parkash, V., Bhagat, G., Tritz, D., Quesada, A. E., Pina-Oviedo, S., Hu, Q., Garcia-Gomez, F. J., Jose Borrero, J., Horna, P., Thakral, B., Narbaitz, M., Hughes, R. C., 3rd, Yang, L. J., Fromm, J. R., Wu, D., Zhang, D., Sohani, A. R., Hunt, J., Vadlamani, I. U., Morgan, E. A., Ferry, J. A., Szigeti, R., C Tardio, J., Granados, R., Dertinger, S., Offner, F. A., Pircher, A., Hosry, J., Young, K. H., & Miranda, R. N. (2018). Clinicopathologic features and prognostic impact of lymph node involvement in patients with breast implant-associated anaplastic large cell lymphoma. The American Journal of Surgical Pathology, 42(3), 203–305.
Letourneau, A., Maerevoet, M., Milowich, D., Dewind, R., Bisig, B., Missiaglia, E., & de Leval, L. (2018, 2018). Dual JAK1 and STAT3 mutations in a breast implant-associated anaplastic large cell lymphoma. Virchow Archiv. https://doi.org/10.1007/s00428-018-2352-y.
Oishi, N., Brody, G. S., Ketterling, R. P., Viswanatha, D. S., He, R., Dasari, S., Mai, M., Benson, H. K., Sattler, C. A., Boddicker, R. L., McPhail, E. D., Bennani, N. N., Harless, C. A., Singh, K., Clemens, M. W., Medeiros, L. J., Miranda, R. N., & Feldman, A. L. (2018). Genetic subtyping of breast implant-associated anaplastic large cell lymphoma. Blood, 132(5), 544–547.
Rupani, A., et al. (2015). Lymphomas associated with breast implants: A review of the literature. Aesthetic Surgery Journal, 35(5), 533–544.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer Nature Switzerland AG
About this entry
Cite this entry
de Leval, L., Milowich, D. (2018). Breast Implant-Associated Malignant Lymphoma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4743-1
Download citation
DOI: https://doi.org/10.1007/978-3-319-28845-1_4743-1
Received:
Accepted:
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-28845-1
Online ISBN: 978-3-319-28845-1
eBook Packages: Springer Reference MedicineReference Module Medicine