Benign and Atypical Apocrine Lesions
Apocrine metaplasia: This is a change of native breast ductal epithelial cells into cells showing eosinophilic granular cytoplasm, a large open nucleus with a single nucleolus, and decapitation secretion. Apocrine metaplasia can be subtyped into simple, papillary, and complex depending on architectural complexity. Apocrine metaplasia can coexist with columnar cell change, sometimes even involving the same duct spaces.
Apocrine adenosis: This is apocrine change in sclerosing adenosis. Some authors use a different definition, as a haphazard proliferation of bland glands with apocrine differentiation and use this term as synonymous with adenomyoepithelial adenosis.
Atypical apocrine change within sclerosing adenosis (atypical apocrine adenosis): Generally seen in postmenopausal women, these cases are defined as having a 3× variation in nuclear size. They have no...
References and Further Reading
- Celis, J. E., Moreira, J. M. A., Gromova, I., Cabezón, T., Gromov, P., Shen, T., Timmermans, V., & Rank, F. (2007). Characterization of breast precancerous lesions and myoepithelial hyperplasia in sclerosing adenosis with apocrine metaplasia. Molecular Oncology, 1, 97–119.CrossRefPubMedPubMedCentralGoogle Scholar