Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Benign and Atypical Apocrine Lesions

  • Reena KhiroyaEmail author
  • Clive Wells
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_4739-1



Apocrine metaplasia: This is a change of native breast ductal epithelial cells into cells showing eosinophilic granular cytoplasm, a large open nucleus with a single nucleolus, and decapitation secretion. Apocrine metaplasia can be subtyped into simple, papillary, and complex depending on architectural complexity. Apocrine metaplasia can coexist with columnar cell change, sometimes even involving the same duct spaces.

Apocrine adenosis: This is apocrine change in sclerosing adenosis. Some authors use a different definition, as a haphazard proliferation of bland glands with apocrine differentiation and use this term as synonymous with adenomyoepithelial adenosis.

Atypical apocrine change within sclerosing adenosis (atypical apocrine adenosis): Generally seen in postmenopausal women, these cases are defined as having a 3× variation in nuclear size. They have no...

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References and Further Reading

  1. Calhoun, B. C., & Booth, C. N. (2014). Atypical apocrine adenosis diagnosed on breast core biopsy: Implications for management. Human Pathology, 45, 2130–2135.CrossRefPubMedGoogle Scholar
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  9. Rosen, P. P. (1985). Papillary duct hyperplasia of the breast in children and young adults. Cancer, 56, 1611–1617.CrossRefPubMedGoogle Scholar
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  11. Seidman, J. D., Ashton, M., & Lefkowitz, M. (1996). Atypical apocrine adenosis of the breast: A clinicopathologic study of 37 patients with 8.7-year follow-up. Cancer, 77, 2529–2537.CrossRefPubMedGoogle Scholar
  12. Selim, A. G. A., Ryan, A., El-Ayat, G., & Wells, C. A. (2002). Loss of heterozygosity and allelic imbalance in apocrine metaplasia of the breast: Microdissection microsatellite analysis. The Journal of Pathology, 196, 287–291.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.University College London HospitalLondonUK