Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Adenosis, Other Types

  • Manuela LacerdaEmail author
  • Paulo Figueiredo
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_4737-1



Adenomyoepithelial adenosis: A benign proliferative lesion characterized by the simultaneous hyperplasia in both glandular and myoepithelial cells of the units of the lobules.

Adenosis tumor: A clinically and/or macroscopically recognizable breast lesion that, histologically, primarily consists of sclerosing adenosis.

Tubular adenosis: A very rare benign lesion composed of disorderly growing, noncrowded narrow tubules that may mimic invasive carcinoma.

Simple adenosis: An increase in size and number of lobules.

Clinical Features


Adenomyoepithelial adenosis: In the literature, few cases are reported.

Adenosis tumor: Rare.

Tubular adenosis: Very rare, only few cases have been reported.

Simple adenosis: Incidental finding in surgical specimens.


Adenomyoepithelial adenosis: The age range is from 30 to 52 years...

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References and Further Reading

  1. Bonser, G. M., Dossett, J. A., & Jull, J. W. (1961). Human and experimental breast cancer. London: Pitman Medical Publications Co. Ltd.Google Scholar
  2. Da Silva, L., Buck, L., Simpson, P. T., Reid, L., McCallum, N., Madigan, B. J., & Lakhani, S. R. (2009). Molecular and morphological analysis of adenoid cystic carcinoma of the breast with synchronous tubular adenosis. Virchows Archive, 454, 107–114.CrossRefGoogle Scholar
  3. DiPiro, P., Gulizia, J. A., Lester, S. C., & Meyer, J. E. (2000). American Journal of Radiology, 175, 31–34.Google Scholar
  4. Erel, S., Tuncbilek, I., Kismet, K., Kilicoglu, B., Ozer, E., & Mehmet, A. A. (2008). Adenomyoepithelial adenosis of the breast: Clinical, radiological and pathological findings for differential diagnosis. Breast Cancer, 3, 427–430.Google Scholar
  5. European guidelines for quality assurance in breast cancer screening and diagnosis. (2006). European Commission, 4th edn 6a (pp. 221–256).Google Scholar
  6. Hamperl, H. (1970) The myoepithelia (myoepithelial cells) normal state; regressive changes; hyperplasia; tumors. In H-W. Altmann, et al., (Eds.), Current topics in pathology (Vol. 53, pp. 161–213). Berlin/Heidelberg: Springer.Google Scholar
  7. Heller, E. L., & Fleming, J. C. (1950). Fibrosing adenomatosis of the breast. American Journal of Clinical Pathology, 20, 141–146.CrossRefPubMedGoogle Scholar
  8. Jung, W.-H., Noh, T.-W., Kim, H.-J., Kim, D.-Y., Lee, H.-D., & K-K, O. (2000). Lobular carcinoma in situ in sclerosing adenosis. Yonsei Medical Journal, 41, 293–297.CrossRefPubMedGoogle Scholar
  9. Kiaer, H., Nielsen, B., Paulsen, S., Sørensen, I. M., Dyrebog, U., & Blichert-Tft, M. (1984). Adenomyoepithelial adenosis and low-grade malignant adenomyoepithelioma of the breast. Virchows Archive (A), 405, 55–67.CrossRefGoogle Scholar
  10. Lee, K. C., Chan, J. K., & Gwi, E. (1996). Tubular adenosis of the breast: A distinctive lesion mimicking invasive carcinoma. American Journal of Surgical Pathology, 20, 46–54.CrossRefPubMedGoogle Scholar
  11. Nielsen, B. B. (1987). Adenosis tumor of the breast – a clinic – pathological investigation of 27cases. Histopathology, 11, 1259–1275.CrossRefPubMedGoogle Scholar
  12. Oberman, H. A. (1984). Benign breast lesions confused with carcinoma. In R. W. McDivtt, H. A. Oberman, L. Ozzello, N. Kaufman (Eds.), The breast. Baltimore: Williams and Wilkins. United States-Canadian Academy of Pathology Monographs in Pathology, 25, 1–33.Google Scholar
  13. Rageth, C. J., O’Flynn, E. A. M., Comstock, C., Kurtz, C., Kubik, R., Madjar, H., Lepori, D., Kampmann, G., Mundinger, A., Baege, A., Decker, T., Hosch, S., Tausch, C., Delaloye, J. F., Morris, E., & Varga, Z. (2016). First International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions). Breast Cancer Research and Treatment, 159, 203–213.CrossRefPubMedPubMedCentralGoogle Scholar
  14. Reston, V. A., & American College of Radiology. (1998). Illustrated breast imaging report and system (BI-RADS), 3rd edn. American College of Radiology 5B 6.Google Scholar
  15. Sloane, J. P. (1985). Non-neoplastic epithelial changes. In J. P. Sloane (Ed.), Biopsy pathology of the breast, Biopsy pathology series (pp. 69–92). London: Chapman and Hall Medical.Google Scholar
  16. Tavassoli, F. A. (1991). Myoepithelial lesions of the breast. Myoepitheliosis, adenomyoepithelioma and myoepithelial carcinoma. American Journal of Surgical Pathology, 15, 554–568.CrossRefPubMedGoogle Scholar
  17. Tsuda, H., Mukai, K., Fukutomi, T., & Hirohashi, S. (1994). Malignant progression of adenomyoepithelial adenosis of the breast. Pathology International, 44, 475–479.CrossRefPubMedGoogle Scholar

Copyright information

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Authors and Affiliations

  1. 1.Instituto de Patologia e Imunologia Molecular da Universidadedo Porto (IPATIMUP)PortoPortugal
  2. 2.Instituto Português de Oncologia de CoimbraCoimbraPortugal