Synonyms
Definition
SA is a lobulocentric proliferation of distorted acini around a central duct with preservation of myoepithelial cells, accompanied with varying degrees of epithelial atrophy and stromal fibrosis.
Clinical Features
Incidence: SA is often an incidental finding in breast tissue removed for other reasons. In autopsy studies performed on patients with no history of breast disease, the incidence of SA was in a range of 7–20%. The lesion is present in 12–28% of breast biopsies without cancer and in 5–7% of malignant biopsies.
Age: Most patients are in their forties and fifties with a peak in the 45–55 age group (34%), versus 28.3% of older women and 21.6% of women less than 45.
Sex: SA is predominant in women and more common in obese and in women using hormone replacement therapy and with a higher fibroglandular breast tissue density at mammography (>25%). Because of increased estrogen receptor (ER) expression observed compared with normal...
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References and Further Reading
Jensen, R. A., Page, D. L., Dupont, W. D., & Rogers, L. W. (1989). Invasive breast cancer risk in women with sclerosing adenosis. Cancer, 64, 1977–1983.
Nassar, A., Hoskin, T. L., Stallings-Mann, M. L., Degnim, A. C., Radisky, D. C., Frost, M. H., Vierkant, R. A., Hartmann, L. C., & Visscher, D. W. (2015). Ki-67 expression in sclerosing adenosis and adjacent normal breast terminal ductal lobular units: A nested case-control study from the Mayo Benign Breast Disease Cohort. Breast Cancer Research and Treatment, 151, 89–97.
Pavlakis, K., Zoubouli, C., Liakakos, T., Messini, I., Keramopoullos, A., Athanassiadou, S., Kafousi, M., & Stathopoulos, E. N. (2006). Myoepithelial cell cocktail (P63+SMA) for the evaluation of sclerosing breast lesions. Breast, 15, 705–712.
Urban, J. A., & Adair, F. E. (1949). Sclerosing adenosis. Cancer, 2, 625–634.
Visscher, D. W., Nassar, A., Degnim, A. C., Frost, M. H., Vierkant, R. A., Frank, R. D., Tarabishy, Y., Radisky, D. C., & Hartmann, L. C. (2014). Sclerosing adenosis and risk of breast cancer. Breast Cancer Research and Treatment, 144, 205–212.
Winham, S. J., Mehner, C., Heinzen, E. P., Broderick, B. T., Stallings-Mann, M., Nassar, A., Vierkant, R. A., Hoskin, T. L., Frank, R. D., Wang, C., Denison, L. A., Vachon, C. M., Frost, M. H., Hartmann, L. C., Aubrey Thompson, E., Sherman, M. E., Visscher, D. W., Degnim, A. C., & Radisky, D. C. (2017). NanoString-based breast cancer risk prediction for women with sclerosing adenosis. Breast Cancer Research and Treatment, 166, 641–650.
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Pekar, G. (2018). Sclerosing Adenosis. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4734-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_4734-1
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