SA is a lobulocentric proliferation of distorted acini around a central duct with preservation of myoepithelial cells, accompanied with varying degrees of epithelial atrophy and stromal fibrosis.
Incidence: SA is often an incidental finding in breast tissue removed for other reasons. In autopsy studies performed on patients with no history of breast disease, the incidence of SA was in a range of 7–20%. The lesion is present in 12–28% of breast biopsies without cancer and in 5–7% of malignant biopsies.
Age: Most patients are in their forties and fifties with a peak in the 45–55 age group (34%), versus 28.3% of older women and 21.6% of women less than 45.
Sex: SA is predominant in women and more common in obese and in women using hormone replacement therapy and with a higher fibroglandular breast tissue density at mammography (>25%). Because of increased estrogen receptor (ER) expression observed compared with normal...
References and Further Reading
- Nassar, A., Hoskin, T. L., Stallings-Mann, M. L., Degnim, A. C., Radisky, D. C., Frost, M. H., Vierkant, R. A., Hartmann, L. C., & Visscher, D. W. (2015). Ki-67 expression in sclerosing adenosis and adjacent normal breast terminal ductal lobular units: A nested case-control study from the Mayo Benign Breast Disease Cohort. Breast Cancer Research and Treatment, 151, 89–97.CrossRefGoogle Scholar
- Winham, S. J., Mehner, C., Heinzen, E. P., Broderick, B. T., Stallings-Mann, M., Nassar, A., Vierkant, R. A., Hoskin, T. L., Frank, R. D., Wang, C., Denison, L. A., Vachon, C. M., Frost, M. H., Hartmann, L. C., Aubrey Thompson, E., Sherman, M. E., Visscher, D. W., Degnim, A. C., & Radisky, D. C. (2017). NanoString-based breast cancer risk prediction for women with sclerosing adenosis. Breast Cancer Research and Treatment, 166, 641–650.CrossRefGoogle Scholar