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Pseudoangiomatous Stromal Hyperplasia

  • Living reference work entry
  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 113 Accesses

Synonyms

Nodular myofibroblastic stromal hyperplasia of the mammary gland (Leon et al. 2002).

Definition

Pseudoangiomatous hyperplasia of mammary stroma (PASH) is a benign proliferation of keloid-like fibrosis, containing slit-like pseudovascular spaces lined by spindle shaped cells without mitotic figures and atypia. (Ibrahim et al. 1989). PASH is considered a breast-specific myofibroblastic proliferation (Krings et al. 2017.

Clinical Features

  • Incidence

    PASH of the breast was first described by Vuitch et al. in 1986 (Vuitch et al. 1986). Its incidence was later investigated in a series of 200 consecutive breast biopsies and surgical specimens and was found to be an incidental finding in breast biopsies in 23% of the cases (Ibrahim et al. 1989). Incidental PASH can be found in fibroadenomas, gynecomastia, normal breast tissue, hamartomas, and sclerosing lobular hyperplasia. It has also been described in surgical specimens of gigantomastia. Two cases were described in immunosuppressed...

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References and Further Reading

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Author information

Authors and Affiliations

  1. 2nd Department of Pathology, Semmelweis University, Budapest, Hungary

    Janina Kulka

  2. Unit of Pathology, Candiolo Cancer Institute FPO-IRCCS, Candiolo, Italy

    Anna Sapino

  3. Department of Medical Sciences, University of Torino, Turin, Italy

    Anna Sapino

Authors
  1. Janina Kulka
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  2. Anna Sapino
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Corresponding author

Correspondence to Janina Kulka .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Kulka, J., Sapino, A. (2019). Pseudoangiomatous Stromal Hyperplasia. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4728-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4728-1

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  • Print ISBN: 978-3-319-28845-1

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