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Polymorphous Carcinoma

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  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

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Synonyms

Polymorphous low-grade adenocarcinoma

Definition

Polymorphous carcinoma is a very rare breast carcinoma with epithelial cell differentiation showing morphological features similar to those referred as polymorphous low-grade adenocarcinoma in salivary glands.

Clinical Features

  • Incidence

    Five cases of this special type of primary breast carcinoma have been reported in literature with morphological description.

  • Age

    Median age at presentation is 55 years, ranging from 37 to 74 years.

  • Sex

    All the patients reported in literature are female.

  • Site

    Breast without the prevalence of a specific mammary quadrant.

  • Treatment

    Wide excision with axillary lymph node dissection is the choice of treatment of the cases reported in the literature, followed by radiotherapy in two patients. Although no lymph node metastases are found, polymorphous carcinoma seems to be an aggressive neoplasm and recommended treatment consists of wide excision with sentinel node biopsy and eventually axillary lymph...

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References

  • Asioli, S., Marucci, G., Ficarra, G., Stephens, M., Foschini, M. P., Ellis, I. O., & Eusebi, V. (2006). Polymorphous adenocarcinoma of the breast. Report of three cases. Virchows Archiv, 448, 29–34.

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  • Elston, C. W., & Ellis, I. O. (1991). Pathological prognostic factors in breast cancer. 1. The value of histological grade in breast cancer: Experience from a large study with long-term follow-up. Histopathology, 19, 403–410.

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  • Foschini, M. P., Morandi, L., Asioli, S., Giove, G., Corradini, A. G., & Eusebi, V. (2017). The morphological spectrum of salivary gland type tumours of the breast. Pathology, 49, 215–227.

    Article  PubMed  Google Scholar 

  • Reyes, C., Jorda, M., & Gomez-Fernández, C. (2013). Salivary gland-like tumors of the breast express basal-type immunohistochemical markers. Applied Immunohistochemistry and Molecular Morphology, 21, 283–286.

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Biomedical and Neuromotor Sciences (DIBINEM), Surgical Pathology Section, Alma Mater Studiorum – University of Bologna, Bologna, Italy

    Sofia Asioli & Costantino Ricci

Authors
  1. Sofia Asioli
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  2. Costantino Ricci
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Corresponding author

Correspondence to Sofia Asioli .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Asioli, S., Ricci, C. (2018). Polymorphous Carcinoma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4727-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4727-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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