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Invasive Secretory Carcinoma

  • Living reference work entry
  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 64 Accesses

Synonyms

Juvenile secretory carcinoma, Juvenile breast carcinoma, Secretory carcinoma.

Definition

Invasive secretory carcinoma (ISC) is one of the rarest histological subtypes of breast cancer, of low-grade and translocation-associated. ISC shows distinctive histological features consisting in intracellular and extracellular production of secretory material.

Clinical Features

  • Incidence: Less than 0.15% of all breast carcinomas (about 200 cases published in English literature).

  • Age: Originally described in children and termed “juvenile secretory carcinoma” (McDivitt and Stewart 1966), it appears that two thirds of the published cases actually occur in adults and very rarely in the elderly. The age range of the reported cases varies from 3 to 91 years.

  • Sex: Mainly observed in adult female and children of both sexes, very rare in men over the age of 30. A case in a male-to-female transgender has been described (Grabellus et al. 2005).

  • Site: ISC may appear in any part of the breast;...

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References and Further Reading

  • Bishop, J. A., Taube, J. M., Su, A., Binder, S. W., Kazakov, D. V., Michal, M., & Westra, W. H. (2017). Secretory carcinoma of the skin harboring ETV6 gene fusion. A cutaneous analogue to secretory carcinomas of the breast and salivary glands. American Journal of Surgical Pathology, 41, 62–66.

    Article  PubMed  Google Scholar 

  • Del Castillo, M., Chibon, F., Arnould, L., Croce, S., Ribeiro, A., Perot, G., Hostein, I., Geha, S., Bozon, C., Garnier, A., Lae, M., Vincent-Salomon, A., & MacGrogan, G. (2015). Secretory breast carcinoma. A Histopathologic and genomic Spectrum characterized by a joint specific ETV6-NTRK3 gene fusion. American Journal of Surgical Pathology, 39, 1458–1467.

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  • Grabellus, F., Worm, K., Willruth, A., Schmitz, K. J., Otterbach, F., Baba, H. A., Kimming, R., & Metz, K. A. (2005). ETV6-NTRK3 gene fusion in a secretory carcinoma of the breast of a male-to-female transsexual. The Breast, 14, 71–74.

    Article  CAS  PubMed  Google Scholar 

  • Koerner, F. C. (2014). Secretory carcinoma. In S. A. Hoda, E. Brogi, F. C. Koerner, & P. P. Rosen (Eds.), ROSEN's BREAST pathology (4th ed., pp. 689–701). Philadelphia: Wolters Kluwer Lippincott Williams & Wilkins.

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  • McDivitt, R. W., & Stewart, F. W. (1966). Breast carcinoma in children. JAMA, 195, 388–390.

    Article  CAS  PubMed  Google Scholar 

  • Tognon, C., Knezevich, S. R., Huntsman, D., Roskelley, C. D., Melnyk, N., Mathers, J. A., Becker, L., Carneiro, F., MacPherson, N., Horsman, D., Poremba, C., & Sorensen, P. H. (2002). Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma. Cancer Cell, 2, 367–376.

    Article  CAS  PubMed  Google Scholar 

  • Toll, A., Joneja, U., & Palazzo, J. (2016). Pathologic spectrum of secretory and mucinous breast lesions. Archives of Pathology and Laboratory Medicine, 140, 644–650.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Medical School, Section of Pathologic Anatomy and Histology, Department of Experimental Medicine, University of Perugia, Perugia, Italy

    Angelo Sidoni

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  1. Angelo Sidoni
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Correspondence to Angelo Sidoni .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Sidoni, A. (2018). Invasive Secretory Carcinoma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4721-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4721-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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