Skip to main content
SpringerLink
Log in

Invasive Metaplastic Carcinoma

  • Living reference work entry
  • Latest version View entry history
  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 79 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References and Further Reading

  • Collins, L. C., & Schnitt, S. (2013). Biopsy interpretation of the breast (2nd ed.). Philadelphia: Lippincott Williams & Wilkins.

    Google Scholar 

  • Geyer, F. C., Weigelt, B., Natrajan, R., Lambros, M. B., de Biase, D., Vatcheva, R., Savage, K., Mackay, A., Ashworth, A., & Reis-Filho, J. S. (2010). Molecular analysis reveals a genetic basis for the phenotypic diversity of metaplastic breast carcinomas. The Journal of Pathology, 220(5), 562–573.

    Article  CAS  Google Scholar 

  • Gobbi, H., Simpson, J. F., Borowsky, A., Jensen, R. A., & Page, D. L. (1999). Metaplastic breast tumors with a dominant fibromatosis-like phenotype have a high risk of local recurrence. Cancer, 85(10), 2170–2182.

    Article  CAS  Google Scholar 

  • Gobbi, H., Simpson, J. F., Jensen, R. A., Olson, S. J., & Page, D. L. (2003). Metaplastic spindle cell breast tumors arising within papillomas, complex sclerosing lesions, and nipple adenomas. Modern Pathology, 16(9), 893–901.

    Article  Google Scholar 

  • Hattori, Y., Yoshida, A., Yoshida, M., Takahashi, M., & Tsuta, K. (2015). Evaluation of androgen receptor and GATA binding protein 3 as immunohistochemical markers in the diagnosis of metastatic breast carcinoma to the lung. Pathology International, 65(6), 286–292.

    Article  CAS  Google Scholar 

  • Hennessy, B. T., Gonzalez-Angulo, A. M., Stemke-Hale, K., Gilcrease, M. Z., Krishnamurthy, S., Lee, J. S., Fridlyand, J., Sahin, A., Agarwal, R., Joy, C., Liu, W., Stivers, D., Baggerly, K., Carey, M., Lluch, A., Monteagudo, C., He, X., Weigman, V., Fan, C., Palazzo, J., Hortobagyi, G. N., Nolden, L. K., Wang, N. J., Valero, V., Gray, J. W., Perou, C. M., & Mills, G. B. (2009). Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics. Cancer Research, 69(10), 4116–4124.

    Article  CAS  Google Scholar 

  • Jung, S. Y., Kim, H. Y., Nam, B. H., Min, S. Y., Lee, S. J., Park, C., Kwon, Y., Kim, E. A., Ko, K. L., Shin, K. H., Lee, K. S., Park, I. H., Lee, S., Kim, S. W., Kang, H. S., & Ro, J. (2010). Worse prognosis of metaplastic breast cancer patients than other patients with triple-negative breast cancer. Breast Cancer Research and Treatment, 120(3), 627–637.

    Article  Google Scholar 

  • Lai, H. W., Tseng, L. M., Chang, T. W., Kuo, Y. L., Hsieh, C. M., Chen, S. T., Kuo, S. J., Su, C. C., & Chen, D. R. (2013). The prognostic significance of metaplastic carcinoma of the breast (MCB)–A case controlled comparison study with infiltrating ductal carcinoma. Breast, 22(5), 968–973.

    Article  Google Scholar 

  • Lakhani, S. R., Ellis, I. O., Schnitt, S. R., Hoon Tan, P., & van de Vijver, M. (2012). WHO classification of tumors of the breast. Lyon: IARC Press.

    Google Scholar 

  • Lehmann, B. D., Bauer, J. A., Chen, X., Sanders, M. E., Chakravarthy, A. B., Shyr, Y., & Pietenpol, J. A. (2011). Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. Journal of Clinical Investigation, 121(7), 2750–2767.

    Article  CAS  Google Scholar 

  • Lehmann, B. D., Jovanović, B., Chen, X., Estrada, M. V., Johnson, K. N., Shyr, Y., Moses, H. L., Sanders, M. E., & Pietenpol, J. A. (2016). Refinement of triple-negative breast cancer molecular subtypes: Implications for neoadjuvant chemotherapy selection. PLoS One, 11(6), e0157368.

    Article  Google Scholar 

  • Lien, H. C., Lin, C. W., Mao, T. L., Kuo, S. H., Hsiao, C. H., & Huang, C. S. (2004). p53 overexpression and mutation in metaplastic carcinoma of the breast: Genetic evidence for a monoclonal origin of both the carcinomatous and the heterogeneous sarcomatous components. The Journal of Pathology, 204(2), 131–139.

    Article  CAS  Google Scholar 

  • Marchio, C., Geyer, F. C., & Reis-Filho, J. S. (2016). Pathology and molecular pathology of breast cancer. In M. Loda et al. (Eds.), Pathology and epidemiology of cancer (pp. 173–232). Cham: Springer International Publishing.

    Google Scholar 

  • Ng, C. K. Y., Piscuoglio, S., Geyer, F. C., Burke, K. A., Pareja, F., Eberle, C. A., Lim, R. S., Natrajan, R., Riaz, N., Mariani, O., Norton, L., Vincent-Salomon, A., Wen, Y. H., Weigelt, B., & Reis-Filho, J. S. (2017). The landscape of somatic genetic alterations in metaplastic breast carcinomas. Clinical Cancer Research, 23(14), 3859–3870.

    Article  CAS  Google Scholar 

  • Pezzi, C. M., Patel-Parekh, L., Cole, K., Franko, J., Klimberg, V. S., & Bland, K. (2007). Characteristics and treatment of metaplastic breast cancer: Analysis of 892 cases from the National Cancer Data Base. Annals of Surgical Oncology, 14(1), 166–173.

    Article  Google Scholar 

  • Tanabe, Y., Tsuda, H., Yoshida, M., Yunokawa, M., Yonemori, K., Shimizu, C., Yamamoto, S., Kinoshita, T., Fujiwara, Y., & Tamura, K. (2017). Pathological features of triple-negative breast cancers that showed progressive disease during neoadjuvant chemotherapy. Cancer Science, 108(7), 1520–1529.

    Article  CAS  Google Scholar 

  • Provenzano, E., Byrne, D. J., Russell, P. A., Wright, G. M., Generali, D., & Fox, S. B. (2016). Differential expression of immunohistochemical markers in primary lung and breast cancers enriched for triple-negative tumours. Histopathology, 68(3), 367–377.

    Article  Google Scholar 

  • Rakha, E. A., Aleskandarany, M. A., Lee, A. H., & Ellis, I. O. (2016). An approach to the diagnosis of spindle cell lesions of the breast. Histopathology, 68(1), 33–44.

    Article  Google Scholar 

  • Rakha, E. A., Coimbra, N. D., Hodi, Z., Juneinah, E., Ellis, I. O., & Lee, A. H. (2017). Immunoprofile of metaplastic carcinomas of the breast. Histopathology, 70(6), 975–985.

    Article  Google Scholar 

  • Reis-Filho, J. S., Milanezi, F., Steele, D., Savage, K., Simpson, P. T., Nesland, J. M., Pereira, E. M., Lakhani, S. R., & Schmitt, F. C. (2006). Metaplastic breast carcinomas are basal-like tumours. Histopathology, 49(1), 10–21.

    Article  CAS  Google Scholar 

  • Reyes, C., Gomez-Fernández, C., & Nadji, M. (2012). Metaplastic and medullary mammary carcinomas do not express mammaglobin. American Journal of Clinical Pathology, 137(5), 747–752.

    Article  Google Scholar 

  • Sneige, N., Yaziji, H., Mandavilli, S. R., Perez, E. R., Ordonez, N. G., Gown, A. M., & Ayala, A. (2001). Low-grade (fibromatosis-like) spindle cell carcinoma of the breast. American Journal of Surgical Pathology, 25(8), 1009–1016.

    Article  CAS  Google Scholar 

  • Weigelt, B., Kreike, B., & Reis-Filho, J. S. (2009). Metaplastic breast carcinomas are basal-like breast cancers: A genomic profiling analysis. Breast Cancer Research and Treatment, 117(2), 273–280.

    Article  CAS  Google Scholar 

  • Weigelt, B., Ng, C. K., Shen, R., Popova, T., Schizas, M., Natrajan, R., Mariani, O., Stern, M. H., Norton, L., Vincent-Salomon, A., & Reis-Filho, J. S. (2015). Metaplastic breast carcinomas display genomic and transcriptomic heterogeneity. Modern Pathology, 28(3), 340–351.

    Article  CAS  Google Scholar 

  • Wendroth, S. M., Mentrikoski, M. J., & Wick, M. R. (2015). GATA3 expression in morphologic subtypes of breast carcinoma: A comparison with gross cystic disease fluid protein 15 and mammaglobin. Annals of Diagnostic Pathology, 19(1), 6–9.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. University of Torino, Torino, Italy

    Caterina Marchiò

  2. Institut Curie, Paris, France

    Caterina Marchiò, Suzanne Chartier, Guillaume Bataillon & Anne Vincent-Salomon

Authors
  1. Caterina Marchiò
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Suzanne Chartier
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Guillaume Bataillon
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Anne Vincent-Salomon
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Anne Vincent-Salomon .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Marchiò, C., Chartier, S., Bataillon, G., Vincent-Salomon, A. (2019). Invasive Metaplastic Carcinoma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4717-2

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4717-2

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

Publish with us

Policies and ethics

Chapter history

  1. Latest

    Invasive Metaplastic Carcinoma
    Published:
    26 November 2018

    DOI: https://doi.org/10.1007/978-3-319-28845-1_4717-2

  2. Original

    Invasive Metaplastic Carcinoma
    Published:
    22 March 2018

    DOI: https://doi.org/10.1007/978-3-319-28845-1_4717-1

Search

Navigation