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Encyclopedia of Pathology pp 1–10Cite as

Invasive Metaplastic Carcinoma

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Part of the book series: Encyclopedia of Pathology ((EP))

Synonyms

Carcinoma with pseudosarcomatous metaplasia; Carcinosarcoma; Matrix-producing carcinoma; Sarcomatoid carcinoma; Spindle cell metaplastic tumor

Definition

Metaplastic carcinomas represent a morphologically heterogeneous group of invasive breast cancers in which a variable proportion of the tumor shows squamous and/or mesenchymal differentiation featuring, for instance, spindle, chondroid, osseous, or rhabdoid cells (Lakhani et al. 2012).

Clinical Features

  • Incidence: Metaplastic carcinomas represent an uncommon histologic type of breast cancer accounting for 0.2–5% of all breast carcinomas (Lakhani et al. 2012).

  • Age: Although the range of age at presentation is similar to that of invasive carcinomas of no special type (IC-NST), two studies have reported an older mean age at presentation in metaplastic carcinomas compared to that of patients affected by IC-NSTs (Lai et al. 2013; Pezzi et al. 2007).

  • Sex: Most of the cases have been described in female patients; however there are...

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References and Further Reading

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  • Gobbi, H., Simpson, J. F., Borowsky, A., Jensen, R. A., & Page, D. L. (1999). Metaplastic breast tumors with a dominant fibromatosis-like phenotype have a high risk of local recurrence. Cancer, 85(10), 2170–2182.

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  • Gobbi, H., Simpson, J. F., Jensen, R. A., Olson, S. J., & Page, D. L. (2003). Metaplastic spindle cell breast tumors arising within papillomas, complex sclerosing lesions, and nipple adenomas. Modern Pathology, 16(9), 893–901.

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  • Weigelt, B., Kreike, B., & Reis-Filho, J. S. (2009). Metaplastic breast carcinomas are basal-like breast cancers: A genomic profiling analysis. Breast Cancer Research and Treatment, 117(2), 273–280.

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  • Weigelt, B., Ng, C. K., Shen, R., Popova, T., Schizas, M., Natrajan, R., Mariani, O., Stern, M. H., Norton, L., Vincent-Salomon, A., & Reis-Filho, J. S. (2015). Metaplastic breast carcinomas display genomic and transcriptomic heterogeneity. Modern Pathology, 28(3), 340–351.

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  • Wendroth, S. M., Mentrikoski, M. J., & Wick, M. R. (2015). GATA3 expression in morphologic subtypes of breast carcinoma: A comparison with gross cystic disease fluid protein 15 and mammaglobin. Annals of Diagnostic Pathology, 19(1), 6–9.

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Authors and Affiliations

  1. University of Torino, Torino, Italy

    Caterina Marchiò

  2. Institut Curie, Paris, France

    Caterina Marchiò, Suzanne Chartier, Guillaume Bataillon & Anne Vincent-Salomon

Authors
  1. Caterina Marchiò
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  2. Suzanne Chartier
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  3. Guillaume Bataillon
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  4. Anne Vincent-Salomon
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Corresponding author

Correspondence to Anne Vincent-Salomon .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Marchiò, C., Chartier, S., Bataillon, G., Vincent-Salomon, A. (2019). Invasive Metaplastic Carcinoma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4717-2

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4717-2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

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Chapter history

  1. Latest

    Invasive Metaplastic Carcinoma
    Published:
    26 November 2018

    DOI: https://doi.org/10.1007/978-3-319-28845-1_4717-2

  2. Original

    Invasive Metaplastic Carcinoma
    Published:
    22 March 2018

    DOI: https://doi.org/10.1007/978-3-319-28845-1_4717-1

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