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Encyclopedia of Pathology pp 1–8Cite as

Invasive Lobular Carcinoma

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Part of the book series: Encyclopedia of Pathology ((EP))

Definition

Invasive lobular carcinoma (ILC) is characterized by noncohesive cells, usually E-cadherin negative, that are dispersed or arranged in single-file linear pattern, but can show several additional architectural patterns (Tavassoli and Eusebi 2009; Lakhani et al. 2012). ILC is frequently associated with lobular carcinoma in situ (LCIS).

Clinical Features

  • Incidence: ILC is the second most common type of breast cancer and constitutes 5–15% of all invasive breast tumors (Lakhani et al. 2012), although incidence varies according to the criteria applied for diagnosis. The incidence of ILC is increasing, especially among postmenopausal women, probably as consequence of hormonal replacement therapy and alcohol abuse (Rakha and Ellis 2010).

  • Age: ILC usually affects peri and postmenopausal women aged 50 or more but it can be seen in a wide age range of patients, from young, in their third decade of life, to elderly women, aged more than 80 years (Tavassoli and Eusebi 2009).

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Authors and Affiliations

  1. Department of Biomedical and Neuromotor Sciences, University of Bologna, Unit of Anatomic Pathology at Bellaria Hospital, Bologna, Italy

    Maria P. Foschini & Luca Morandi

Authors
  1. Maria P. Foschini
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  2. Luca Morandi
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Correspondence to Maria P. Foschini .

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Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Foschini, M.P., Morandi, L. (2018). Invasive Lobular Carcinoma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4716-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4716-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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