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Encyclopedia of Pathology pp 1–5Cite as

Invasive Carcinoma with Neuroendocrine Differentiation

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Part of the book series: Encyclopedia of Pathology ((EP))

Synonyms

Carcinoid tumor of the breast; Endocrine carcinoma

Definition

Invasive carcinoma with neuroendocrine (NE) differentiation presents microscopic features similar to NE neoplasms of other organs.

Bussolati and Badve (2012) classifies invasive carcinomas with NE differentiation into three subtypes: well-differentiated NE tumors, poorly differentiated neuroendocrine carcinomas/small cell carcinomas, and invasive carcinomas with NE differentiation.

Clinical Features

  • Incidence: Invasive breast carcinomas with NE features are rare and represent less than 5% of the breast cancers (Wang et al. 2014).

  • Age: Most patients are in the sixth or seventh decades of life.

  • Sex: There is a female predilection. Single case reports of invasive breast carcinomas with NE features in male patients were occasionally described.

  • Site: Usually, invasive breast carcinomas with NE differentiation present unilaterally, nevertheless a single case report with bilateral primary breast NE carcinoma in a young...

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References and Further Reading

  • Bogina, G., Munari, E., Brunelli, M., Bortesi, L., Marconi, M., Sommaggio, M., Lunardi, G., Gori, S., Massocco, A., Pegoraro, M. C., & Zamboni, G. (2016). Neuroendocrine differentiation in breast carcinoma: Clinicopathological features and outcome. Histopathology, 68, 422–432.

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  • Bussolati, G., & Badve, S. (2012). Carcinoma with neuroendocrine features. In S.R. Lakhani, I.O. Ellis, S. J. Schnitt, P. H. Tan, M. J. van de Vijver (Eds). WHO Classification of Tumours of the Breast (pp 62–63) Lyon: IARC

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  • Inno, A., Bogina, G., Turazza, M., Bortesi, L., Duranti, S., Massocco, A., Zamboni, G., Carbognin, G., Alongi, F., Salgarello, M., & Gori, S. (2016). Neuroendocrine carcinoma of the breast: Current evidence and future perspectives. The Oncologist, 21, 28–32.

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  • Kwon, S. Y., Bae, Y. K., Gu, M. J., Choi, J. E., Kang, S. H., Lee, S. J., Kim, A., Jung, H. R., Kang, S. H., Oh, H. K., & Park, J. Y. (2014). Neuroendocrine differentiation correlates with hormone receptor expression and decreased survival in patients with invasive breast carcinoma. Histopathology, 64, 647–659.

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  • Lavigne, M., Menet, E., Tille, J. C., Lae, M., Fuhrmann, L., Bonneau, C., Deniziaut, G., Melaabi, S., Ng, C. C. K., Marchiò, C., Rouzier, R., Bièche, I., & Vincent-Salomon, A. (2017). Comprehensive clinical and molecular analyses of neuroendocrine carcinomas of the breast. Modern Pathology. https://doi.org/10.1038/modpathol.2017.107. [Epub ahead of print].

  • Marchiò, C., Geyer, F. C., Ng, C. K., Piscuoglio, S., De Filippo, M. R., Cupo, M., Schultheis, A. M., Lim, R. S., Burke, K. A., Guerini-Rocco, E., Papotti, M., Norton, L., Sapino, A., Weigelt, B., & Reis-Filho, J. S. (2017). The genetic landscape of breast carcinomas with neuroendocrine differentiation. The Journal of Pathology, 241, 405–419.

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  • Righi, L., Sapino, A., Marchiò, C., Papotti, M., & Bussolati, G. (2010). Neuroendocrine differentiation in cancer: Established facts and unresolved problems. Seminars in Diagnostic Pathology, 27, 69–76.

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  • Sapino, A., Righi, L., Cassoni, P., Papotti, M., Pietribiasi, F., & Bussolati, G. (2000). Expression of the neuroendocrine phenotype in carcinomas of the breast. Seminars in Diagnostic Pathology, 17, 127–137.

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  • Sapino, A., Papotti, M., Righi, L., Cassoni, P., Chiusa, L., & Bussolati, G. (2001a). Clinical significance of neuroendocrine carcinoma of the breast. Annals of Oncology, 12(Suppl 2), S115–S117.

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  • Sapino, A., Righi, L., Cassoni, P., Papotti, M., Gugliotta, P., & Bussolati, G. (2001b). Expression of apocrine differentiation markers in neuroendocrine breast carcinomas of aged women. Modern Pathology, 14, 768–776.

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  • Wang, J., Wei, B., Albarracin, C. T., Hu, J., Abraham, S. C., & Wu, Y. (2014). Invasive neuroendocrine carcinoma of the breast: A population-based study from the surveillance, epidemiology and end results (SEER) database. BMC Cancer, 4(14), 147–156.

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  • Xiang, D. B., Wei, B., Abraham, S. C., Huo, L., Albarracin, C. T., Zhang, H., Babiera, G., Caudle, A. S., Akay, C. L., Rao, P., Zhao, Y. J., Lu, X., & Wu, Y. (2014). Molecular cytogenetic characterization of mammary neuroendocrine carcinoma. Human Pathology, 45, 1951–1956.

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  • Zhang, J.-Y., & Chen, W.-J. (2011). Bilateral primary breast neuroendocrine carcinoma in a young woman: Report a case. Surgery Today, 41, 1575–1578.

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Authors and Affiliations

  1. Tumor Pathology Department, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

    Ewa Chmielik

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  1. Ewa Chmielik
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Correspondence to Ewa Chmielik .

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Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Chmielik, E. (2018). Invasive Carcinoma with Neuroendocrine Differentiation. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4715-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4715-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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