Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Invasive Carcinoma with Neuroendocrine Differentiation

  • Ewa ChmielikEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_4715-1



Invasive carcinoma with neuroendocrine (NE) differentiation presents microscopic features similar to NE neoplasms of other organs.

Bussolati and Badve (2012) classifies invasive carcinomas with NE differentiation into three subtypes: well-differentiated NE tumors, poorly differentiated neuroendocrine carcinomas/small cell carcinomas, and invasive carcinomas with NE differentiation.

Clinical Features

  • Incidence: Invasive breast carcinomas with NE features are rare and represent less than 5% of the breast cancers (Wang et al. 2014).

  • Age: Most patients are in the sixth or seventh decades of life.

  • Sex: There is a female predilection. Single case reports of invasive breast carcinomas with NE features in male patients were occasionally described.

  • Site: Usually, invasive breast carcinomas with NE differentiation present unilaterally, nevertheless a single case report with bilateral primary breast NE carcinoma in a young...

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References and Further Reading

  1. Bogina, G., Munari, E., Brunelli, M., Bortesi, L., Marconi, M., Sommaggio, M., Lunardi, G., Gori, S., Massocco, A., Pegoraro, M. C., & Zamboni, G. (2016). Neuroendocrine differentiation in breast carcinoma: Clinicopathological features and outcome. Histopathology, 68, 422–432.CrossRefPubMedGoogle Scholar
  2. Bussolati, G., & Badve, S. (2012). Carcinoma with neuroendocrine features. In S.R. Lakhani, I.O. Ellis, S. J. Schnitt, P. H. Tan, M. J. van de Vijver (Eds). WHO Classification of Tumours of the Breast (pp 62–63) Lyon: IARCGoogle Scholar
  3. Inno, A., Bogina, G., Turazza, M., Bortesi, L., Duranti, S., Massocco, A., Zamboni, G., Carbognin, G., Alongi, F., Salgarello, M., & Gori, S. (2016). Neuroendocrine carcinoma of the breast: Current evidence and future perspectives. The Oncologist, 21, 28–32.CrossRefPubMedGoogle Scholar
  4. Kwon, S. Y., Bae, Y. K., Gu, M. J., Choi, J. E., Kang, S. H., Lee, S. J., Kim, A., Jung, H. R., Kang, S. H., Oh, H. K., & Park, J. Y. (2014). Neuroendocrine differentiation correlates with hormone receptor expression and decreased survival in patients with invasive breast carcinoma. Histopathology, 64, 647–659.CrossRefPubMedGoogle Scholar
  5. Lavigne, M., Menet, E., Tille, J. C., Lae, M., Fuhrmann, L., Bonneau, C., Deniziaut, G., Melaabi, S., Ng, C. C. K., Marchiò, C., Rouzier, R., Bièche, I., & Vincent-Salomon, A. (2017). Comprehensive clinical and molecular analyses of neuroendocrine carcinomas of the breast. Modern Pathology.  https://doi.org/10.1038/modpathol.2017.107. [Epub ahead of print].
  6. Marchiò, C., Geyer, F. C., Ng, C. K., Piscuoglio, S., De Filippo, M. R., Cupo, M., Schultheis, A. M., Lim, R. S., Burke, K. A., Guerini-Rocco, E., Papotti, M., Norton, L., Sapino, A., Weigelt, B., & Reis-Filho, J. S. (2017). The genetic landscape of breast carcinomas with neuroendocrine differentiation. The Journal of Pathology, 241, 405–419.CrossRefPubMedGoogle Scholar
  7. Righi, L., Sapino, A., Marchiò, C., Papotti, M., & Bussolati, G. (2010). Neuroendocrine differentiation in cancer: Established facts and unresolved problems. Seminars in Diagnostic Pathology, 27, 69–76.CrossRefPubMedGoogle Scholar
  8. Sapino, A., Righi, L., Cassoni, P., Papotti, M., Pietribiasi, F., & Bussolati, G. (2000). Expression of the neuroendocrine phenotype in carcinomas of the breast. Seminars in Diagnostic Pathology, 17, 127–137.PubMedGoogle Scholar
  9. Sapino, A., Papotti, M., Righi, L., Cassoni, P., Chiusa, L., & Bussolati, G. (2001a). Clinical significance of neuroendocrine carcinoma of the breast. Annals of Oncology, 12(Suppl 2), S115–S117.CrossRefPubMedGoogle Scholar
  10. Sapino, A., Righi, L., Cassoni, P., Papotti, M., Gugliotta, P., & Bussolati, G. (2001b). Expression of apocrine differentiation markers in neuroendocrine breast carcinomas of aged women. Modern Pathology, 14, 768–776.CrossRefPubMedGoogle Scholar
  11. Wang, J., Wei, B., Albarracin, C. T., Hu, J., Abraham, S. C., & Wu, Y. (2014). Invasive neuroendocrine carcinoma of the breast: A population-based study from the surveillance, epidemiology and end results (SEER) database. BMC Cancer, 4(14), 147–156.CrossRefGoogle Scholar
  12. Xiang, D. B., Wei, B., Abraham, S. C., Huo, L., Albarracin, C. T., Zhang, H., Babiera, G., Caudle, A. S., Akay, C. L., Rao, P., Zhao, Y. J., Lu, X., & Wu, Y. (2014). Molecular cytogenetic characterization of mammary neuroendocrine carcinoma. Human Pathology, 45, 1951–1956.CrossRefPubMedGoogle Scholar
  13. Zhang, J.-Y., & Chen, W.-J. (2011). Bilateral primary breast neuroendocrine carcinoma in a young woman: Report a case. Surgery Today, 41, 1575–1578.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Tumor Pathology DepartmentMaria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice BranchGliwicePoland