Definition
The WHO Classification of Tumors of the Breast recommends the use of the collective term “Carcinoma with Medullary Features” to encompass tumors previously diagnosed as classical medullary carcinoma (classical MC), atypical medullary carcinoma (atypical MC), and a subgroup of invasive breast carcinoma of no special type (NST) with medullary characteristics (Lakhani et al. 2012).
These tumors are characterized by the following histological features:
- 1.
An expansile or pushing border
- 2.
A syncytial growth pattern
- 3.
High cytonuclear grade
- 4.
A prominent lymphoplasmacytic infiltrate
These diagnostic criteria are less strict than the original criteria proposed by Ridolfi et al. for a diagnosis of classical MC which requires complete circumscription, a syncytial growth...
References and Further Reading
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Quinn, C., D’Arcy, C. (2018). Invasive Carcinoma with Medullary Features. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4714-2
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DOI: https://doi.org/10.1007/978-3-319-28845-1_4714-2
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Invasive Carcinoma with Medullary Features- Published:
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DOI: https://doi.org/10.1007/978-3-319-28845-1_4714-2
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Invasive Carcinoma with Medullary Features- Published:
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DOI: https://doi.org/10.1007/978-3-319-28845-1_4714-1