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Encyclopedia of Pathology pp 1–3Cite as

Invasive Cribriform Carcinoma

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Part of the book series: Encyclopedia of Pathology ((EP))

Synonyms

Invasive cribriform carcinoma; Pure invasive cribriform carcinoma

Definition

A special type of invasive carcinoma with an excellent prognosis that grows in a pattern similar to that seen in intraductal cribriform carcinoma.

Clinical Features

  • Incidence: Invasive cribriform carcinoma accounts for 0.3–0.8% of breast carcinomas (Venable et al. 1990; Li et al. 2005; Louwman et al. 2007); however, a frequency of up to 4% has been reported in some series (Page et al. 1983; Venable et al. 1990).

  • Age: Mean patient age is 53–58 years (Venable et al. 1990).

  • Sex: Female; rare in male as for other forms of breast cancer.

  • Site: Anywhere in the breast but most frequent in the upper outer quadrant like other types of breast cancer.

  • Treatment: Local control and hormone therapy are the main treatment options. Even when patients have axillary metastases from pure invasive cribriform carcinoma, the prognosis is good. The use of systemic adjuvant chemotherapy is typically not needed in pure...

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References

  • Ellis, I. O., Galea, M., Broughton, N., Locker, A., Blamey, R. W., & Elston, C. W. (1992). Pathological prognostic factors in breast cancer. II. Histological type. Relationship with survival in a large study with long-term follow-up. Histopathology, 20, 479–489.

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  • Li, C. I., Uribe, D. J., & Daling, J. R. (2005). Clinical characteristics of different histologic types of breast cancer. British Journal of Cancer, 93, 1046–1052.

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  • Louwman, M. W., Vriezen, M., van Beek, M. W., Nolthenius-Puylaert, M. C., van der Sangen, M. J., Roumen, R. M., Kiemeney, L. A., & Coebergh, J. W. (2007). Uncommon breast tumors in perspective: Incidence, treatment and survival in the Netherlands. International Journal of Cancer, 121, 127–135.

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  • Page, D. L., Dixon, J. M., Anderson, T. J., Lee, D., & Stewart, H. J. (1983). Invasive cribriform carcinoma of the breast. Histopathology, 7, 525–536.

    Article  CAS  Google Scholar 

  • Venable, J. G., Schwartz, A. M., & Silverberg, S. G. (1990). Infiltrating cribriform carcinoma of the breast: A distinctive clinicopathologic entity. Human Pathology, 21, 333–338.

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  • Wells, C. A., & Ferguson, D. J. (1988). Ultrastructural and immunocytochemical study of a case of invasive cribriform breast carcinoma. Journal of Clinical Pathology, 41, 17–20.

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Author information

Authors and Affiliations

  1. Department of Histopathology, Division of Cancer and Stem Cells, University of Nottingham, Nottingham, UK

    Emad Rakha

Authors
  1. Emad Rakha
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Corresponding author

Correspondence to Emad Rakha .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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Cite this entry

Rakha, E. (2018). Invasive Cribriform Carcinoma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4713-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4713-1

  • Received:

  • Accepted:

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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