Synonyms
Definition
Fibroadenoma (FA) is a common benign neoplasm of the breast. It is classically defined as a biphasic lesion, meaning a proliferation of both the epithelial and stromal component.
Clinical Features
Age & Sex
FA has been described at any age, but it occurs mainly in young women of reproductive age. Juvenile FA occurs at ages between 10 and 18 years (Wechselberger et al. 2002).
Site
It may be multiple and bilateral, with no site preference.
Imaging
Mammography can detect FA if a calcific component is present, otherwise it cannot distinguish FAs and cysts. FA is a round or ovoid hypoechoic lesion at ultrasound evaluation.
Treatment & Outcome
FAs are painless lesions with slow growth thus they do not require any treatment, but imaging follow up. About 10% to 40% of FAs resolve spontaneously or if completely excised they do not recur (Song et al. 2014). Cases of juvenile FA (see below) can grow rapidly and occupy most of the breast resulting...
This is a preview of subscription content, log in via an institution to check access.
References and Further Reading
Calcaterra, V., Coscia, D. R., Sgarell, A., Burroni, B., Podetta, M., Andorno, A., Ferrari, A., & Larizza, D. (2009). Recurrence of giant juvenile breast fibroadenoma in a girl with Turner’s syndrome. Journal of Pediatric Endocrinology and Metabolism, 22, 281–283.
Dupont, W. D., Page, D. L., Parl, F. F., Vnencak-Jones, C. L., Plummer, W. D., Jr., Rados, M. S., & Schuyler, P. A. (1994). Long term risk of bresat cancer in woman with fibroadenoma. New England Journal of Medicine, 331, 10–15.
Hoda, S. A., Brogi, E., Koerner, F. C., & Rosen, P. P. (2014). Rosen’s breast pathology (pp. 213–232). Philadelphia: Lippincott Williams & Wilkins.
Kuijper, A., Mommers, E. C. M., van der Wall, E., & van Diest, P. J. (2001). Histopathology of fibroadenoma of the breast. American Journal of Clinical Pathology, 115, 736–742.
Loke, B. N., Nasir, N. D., Thike, A. A., Lee, J. Y. H., Lee, C. S., Teh, B. T., & Tan, P. H. (2018). Genetics and genomics of breast fibroadenomas. Journal of Clinical Pathology, 71, 381–387.
Page, D. L., & Anderson, T. J. (1987). Diagnostic histopathology of the breast (p. 362). Edinburgh: Churchill Livingstone.
Song, B. S., Kim, E. K., Seol, H., et al. (2014). Giant juvenile fibroadenoma of the breast: A case report and brief literature review. Annals of Pediatric Endocrinology & Metabolism, 19, 45–48.
Volckmar, A. L., Leichsenring, J., Flechtenmacher, C., et al. (2017). Tubular, lactating, and ductal adenomas are devoid of MED12 Exon2 mutations, and ductal adenomas show recurrent mutations in GNAS and the PI3K–AKT pathway. Genes, Chromosomes & Cancer, 56, 11–17.
Wechselberger, G., Schoeller, T., & Piza-Katzer, H. (2002). Juvenile fibroadenoma of the breast. Surgery, 132, 106–107.
Yasir, S., Gamez, R., Jenkins, S., Visscher, D. W., & Nassar, A. (2014). Significant histological features differentiating cellular fibroadenoma from phyllodes tumor on core needle biopsies. American Journal of Clinical Pathology, 142, 362–369.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this entry
Cite this entry
Maldi, E., Sapino, A. (2019). Fibroadenoma. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4708-1
Download citation
DOI: https://doi.org/10.1007/978-3-319-28845-1_4708-1
Received:
Accepted:
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-28845-1
Online ISBN: 978-3-319-28845-1
eBook Packages: Springer Reference MedicineReference Module Medicine