Adenomyoepithelioma (AME) is a benign tumor of the breast, composed by a biphasic proliferation of phenotypically distinct myoepithelial cells and luminal epithelial cells.
Following the first description by Hamperl (1970), Tavassoli (1991) identified three histologic variants, in which myoepithelial and epithelial cells are present in variable percentages, namely, spindle, tubular, and lobulated AME (Tavassoli 1991).
AME with malignant features have seldom been reported (Hayes 2011) and named AME with carcinoma, when epithelial cells or myoepithelial cells show malignant cytomorphological features and malignant AME when these are present in both components (Brogi 2014).
References and Further Reading
- Ahmed, A. A., & Heller, D. S. (2000). Malignant adenomyoepithelioma of the breast with malignant proliferation of epithelial and myoepithelial elements: A case report and review of the literature. Archives of Pathology & Laboratory Medicine, 124, 632–636.Google Scholar
- Brogi, E. (2014). Myoepithelial neoplasms. In S. A. Hoda, E. Brogi, F. C. Koerner, & P. P. Rosen (Eds.), Rosen’s breast pathology (4th ed., pp. 153–182). Philadelphia: Wolters Kluver, Lippincott Williams & Wilkins.Google Scholar
- Buch, A., Rout, P., & Makhaija, P. (2006). Adenomyoepithelioma with philloides tumor – A rare combination in a solitary breast lump. Indian Journal of Pathology & Microbiology, 49, 259–261.Google Scholar
- Dewar, R., Fadare, O., & Gilmore, H. (2011). Best practices in diagnostic immunohistochemistry: Myoepithelial markers in breast pathology. Archives of Pathology & Laboratory Medicine, 135, 422–429.Google Scholar
- Eusebi, V., Casadei, G. P., & Bussolati, G. (1987). Adenomyoepithelioma of the breast. A spectrum of biologic behavior. The American Journal of Surgical Pathology, 16, 868–876.Google Scholar
- Hamperl, H. (1970). Normal state, regressive changes, hyperplasia, tumors. Current Topics in Pathology, 53, 194–198.Google Scholar
- Han, J. S., & Peng, Y. (2010). Multicentric adenomyoepithelioma of the breast with atypia and associated ductal carcinoma in situ. Breast J, 16, 547–549.Google Scholar
- Oba, T., Maeno, K., Ono, M., Iesato, A., Ito, T., Kanai, T., Mochizuki, Y., Ito, K.I., Yoshizawa, A. & Takayama, F. (2017). A case of adenomyoepithelioma of the breast showing strong uptake of 18 F-Fluorodeoxyglucose on a positron emission tomography. Breast J, 23, 220–224.Google Scholar
- Qureshi, A., Kayani, N., & Gulzar, R. (2009). Malignant adenomyoepithelioma of the breast: A case report with review of literature. BML Case Reports, 2009.Google Scholar
- Reid-Nicholson, M., Bleiwess, I., & Pace, B. (2003). Pleomorphic adenoma of the breast. A case report and distinction from mucinous carcinoma. Archives of Pathology & Laboratory Medicine, 127, 474–477.Google Scholar