Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Acinic Cell Carcinoma

  • Maria P. FoschiniEmail author
  • Luca Morandi
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_4696-1

Definition

Acinic cell carcinoma (ACC) is a special type of breast carcinoma showing serous differentiation, with zymogen-type cytoplasmic granules, similar to acinic cell carcinoma arising in the parotid gland (Eusebi et al. 2012; Foschini et al. 2017).

Clinical Features

  • Incidence

    ACC is a rare tumor, but its real incidence is difficult to assess, as most of our knowledge is based on single case reports or small series. It was first described by Roncaroli et al. (1996), and then better delineated by Damiani et al. (2000). Since then less than 50 cases have been described in the English literature (Foschini et al. 2017).

  • Age

    ACC usually affects adults, aged from 20 to 80 years (mean 50).

  • Sex

    ACC usually occurs in female patients. One case has been described in a male patient (Shimao et al. 1998) and one case has been reported in BRCA1 mutated patient (Ripamonti et al. 2013).

  • Site

    Breast ACC affects the word breast is repeated therefoe here t can be cancelled parenchyma with no specific...

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References and Further Reading

  1. Clement, P. B., & Azzopardi, J. G. (1983). Microglandular adenosis of the breast – A lesion simulating tubular carcinoma. Histopathology, 7, 169–180.CrossRefPubMedGoogle Scholar
  2. Conlon, N., Sadri, N., Corben, A. D., & Tan, L. K. (2016). Acinic cell carcinoma of breast: Morphologic and immunohistochemical review of a rare breast cancer subtype. Human Pathology, 51, 16–24.CrossRefPubMedPubMedCentralGoogle Scholar
  3. Damiani, S., Pasquinelli, G., Lamovec, J., Peterse, J. L., & Eusebi, V. (2000). Acinic cell carcinoma of the breast: An immunohistochemical and ultrastructural study. Virchows Archiv, 437, 74–81.CrossRefPubMedGoogle Scholar
  4. Eusebi, V., Ichihara, S., Vincent-Salomon, A., Sniege, A., & Sapino, A. (2012). Exceptionally rare types and variants. In S. R. Lakhani, I. O. Ellis, S. J. Schnitt, P. H. Tan, & M. van de Vijver (Eds.), WHO classification of tumours of the breast (4th ed., p. 75). Lyon: IARC Press.Google Scholar
  5. Foschini, M. P., Morandi, L., Asioli, S., Giove, G., Corradini, A. G., & Eusebi, V. (2017). The morphological spectrum of salivary gland type tumours of the breast. Pathology, 49, 215–227.CrossRefPubMedGoogle Scholar
  6. Guerini-Rocco, E., Hodi, Z., Piscuoglio, S., Ng, C. K., Rakha, E. A., Schultheis, A. M., Marchiò, C., da Cruz, P. A., De Filippo, M. R., Martelotto, L. G., De Mattos-Arruda, L., Edelweiss, M., Jungbluth, A. A., Fusco, N., Norton, L., Weigelt, B., Ellis, I. O., & Reis-Filho, J. S. (2015). The repertoire of somatic genetic alterations of acinic cell carcinomas of the breast: An exploratory, hypothesis-generating study. Journal of Pathology, 237, 166–178.CrossRefPubMedPubMedCentralGoogle Scholar
  7. Piscuoglio, S., Hodi, Z., Katabi, N., Guerini-Rocco, E., Macedo, G. S., Ng, C. K., Edelweiss, M., De Mattos-Arruda, L., Wen, H. Y., Rakha, E. A., Ellis, I. O., Rubin, B. P., Weigelt, B., & Reis-Filho, J. S. (2015). Are acinic cell carcinomas of the breast and salivary glands distinct diseases? Histopathology, 67, 529–537.CrossRefPubMedPubMedCentralGoogle Scholar
  8. Ripamonti, C. B., Colombo, M., Mondini, P., Siranoush, M., Peissel, B., Bernard, L., Radice, P., & Carcangiu, M. L. (2013). First description of an acinic cell carcinoma of the breast in a BRCA1 mutation carrier: A case report. BMC Cancer, 13, 46.CrossRefPubMedPubMedCentralGoogle Scholar
  9. Roncaroli, F., Lamovec, J., Zidar, A., & Eusebi, V. (1996). Acinic cell-like carcinoma of the breast. Virchows Archiv, 429, 69–74.CrossRefPubMedGoogle Scholar
  10. Shimao, K., Haga, S., Shimizu, T., Imamura, H., Watanabe, O., Kinoshita, J., Nagumo, H., Utada, Y., Okabe, T., Kajiwara, T., Oshibe, N., & Aiba, M. (1998). Acinic cell adenocarcinoma arising in the breast of a young male: A clinicopathological, immunohistochemical and ultrastructural study. Breast Cancer, 5, 77–81.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Biomedical and Neuromotor Sciences (DIBINEM)University of BolognaBolognaItaly