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Sclerosing Pneumocytoma, Lung

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  • First Online:
Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 56 Accesses

Synonyms

Sclerosing haemangioma (now defunct).

Definition

A benign neoplasm derived from peripheral lung epithelium showing histological heterogeneity; solid cellular, sclerotic, hemorrhagic, and papillary areas are variably represented. Typically there is a dual cell population, those lining the papillae and glandular spaces and those rounded cells of the solid intervening tissue.

Clinical Features

Incidence

Although the commonest of the truly benign pulmonary neoplasms, these are still rare lesions. Rarer still in Caucasian populations, this lesion is more prevalent in East Asia where it matches typical carcinoid in case numbers.

Age

There is a wide age range for reported cases, from teenage years to the elderly, but most patients are in their 40s or 50s.

Sex

There is a marked female predominance to a ratio of nearly 5:1.

Site

These are lesions which are now recognized as arising from the peripheral lung epithelial compartment so that they tend to be peripheral and parenchymal in...

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References and Further Reading

  • Chan, A. C., & Chan, J. K. (2000). Pulmonary sclerosing hemangioma consistently expresses thyroid transcription factor-1 (TTF-1): A new clue to its histogenesis. American Journal of Surgical Pathology, 24, 531–536.

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  • Devouassoux-Shisheboran, M., Hayashi, T., Linnoila, R. I., et al. (2000). A clinicopathologic study of 100 cases of pulmonary sclerosing hemangioma with immunohistochemical studies: TTF-1 is expressed in both round and surface cells, suggesting an origin from primitive respiratory epithelium. American Journal of Surgical Pathology, 24, 906–916.

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  • Flieder, D. B. (2013). Benign epithelial neoplasms and tumour-like proliferations of the lung. In P. S. Hasleton & D. B. Flieder (Eds.), Spencer’s pathology of the lung. Cambridge: Cambridge University Press.

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  • Katzenstein, A. L., Gmelich, J. T., & Carrington, C. B. (1980). Sclerosing haemangioma of the lung; A clinicopathological study of 51 cases. American Journal of Surgical Pathology, 4, 343–356.

    Article  CAS  PubMed  Google Scholar 

  • Travis, W. D., Brambilla, E., Burke, A. P., Marx, A., & Nicholson, A. N. (Eds.). (2015). WHO classification of tumours of the lung, pleura, thymus and heart. Geneva: WHO Press.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pathology, Aberdeen University Medical School, Aberdeen Royal Infirmary, Aberdeen, UK

    Keith M Kerr

Authors
  1. Keith M Kerr
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Corresponding author

Correspondence to Keith M Kerr .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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© 2017 Springer International Publishing AG

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Kerr, K.M. (2017). Sclerosing Pneumocytoma, Lung. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4358-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4358-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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