Synonyms
Definition
Posttransplant lymphoproliferative disorders (PTLD) comprise a heterogeneous group of condition, with lymphoid and plasmacytoid morphology, associated with iatrogenic immune suppression, in their pure form, after transplantation, most commonly of solid organs. They are closely allied in etiology and histopathological appearance to other forms of lymphoid proliferations seen in patients with disordered immunity, for instance, following prolonged chemotherapy. The condition represents a spectrum of abnormality of lymphoid proliferation, from a polytypic variety often curable on cessation of immune suppression to high-grade lymphoid neoplasia which behaves in line with tumors with similar morphology, immunocytochemistry, and genomic aberrations as found in apparently immune-competent patients.
Clinical Features
Incidence
The risk of patients developing PTLD varies with the organ transplanted. This relates to the degree of immune suppression required to prevent...
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References and Further Reading
Roman, M., Parmarb, J., Goddardc, M., & Sollia, P. (2016). Native lung pneumonectomy for post-transplantation lymphoproliferative disorder refractory to rituximab following contralateral lung transplantation. Interactive Cardiovascular and Thoracic Surgery, 23, 841–843.
Sarkozy, C., Kaltenbach, S., Faurie, P., Canioni, D., Berger, F., Traverse-Glehen, A., Ghesquieres, H., Salles, G., Bachy, E., Alyanakian, M.-A., Hermine, O., Neven, B., Macintyre, E., Romana, S., Molina, T. J., Suarez, F., Asnafi, V., & Bruneau, J. (2017). Array-CGH predicts prognosis in plasma cell post-transplantation lymphoproliferative disorders. Genes, Chromosomes & Cancer, 56, 221–230.
Swerdlow, S. H., Campo, E., Pileri, S. A., Harris, L. N., Stein, H., Siebert, R., Advani, R., Ghielmini, M., Salles, G. A., Zelenetz, A. D., & Jaffe, E. S. (2016). The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood, 127, 2375–2390.
Swerdlow, S. H., Webber, S. A., Chaburn, A., & Ferry, J. A. (2008). Post-transplant lymphoproliferative disorders. In S. H. Swerdlow et al. (Eds.), WHO classification of tumours of haematopoietic and lymphoid tissues (pp. 343–349). Lyon: IARC. ISBN:978-92-832-2431-0.
Tsai, H.-I., & Yu, H.-P. (2016). A review of nationwide population study of organ transplantation in Taiwan. Acta Anaesthesiologica Taiwanica, 54, 70–74.
Wudhikarn, K., Holman, C. J., Linan, M., Blaes, A. H., Dunitz, J. M., Hertz, M. E., & Peterson, B. A. (2011). Post-transplant lymphoproliferative disorders in lung transplant recipients: 20-yr experience at the University of Minnesota. Clinical Transplantation, 25, 705–713.
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Johnston, P.W., Jorgensen, J.L. (2018). Transplant-Associated Lymphoproliferative Disorders. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4357-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_4357-1
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