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Basaloid Carcinoma, Lung

  • Living reference work entry
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Encyclopedia of Pathology

Part of the book series: Encyclopedia of Pathology ((EP))

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Synonyms

Basaloid squamous cell carcinoma; Basaloid variant of squamous cell carcinoma

Definition

A poorly differentiated malignant epithelial tumor that is considered a variant of squamous cell carcinoma. It has features (small cells, lobular architecture with peripheral palisading, high mitotic rate) shared with basal cell or basaloid carcinomas in other organs, e.g., skin and anal canal. Fully formed squamous features are absent, but the immunophenotype is consistently of squamous type. Tumors showing 50% of more of this histology, but with areas of typical squamous cell carcinoma, are still regarded as basaloid carcinoma. The term used in the WHO 2015 classification is basaloid squamous cell carcinoma.

Clinical Features

  • Incidence

    This is a rare tumor, perhaps accounting for 3–6% of cases in surgically resected series, but published data are confounded by variations in definition since the lesion was first described by Brambilla and colleagues in 1992. Until the publication of the...

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References and Further Reading

  • Brambilla, E., Moro, D., Veale, D., et al. (1992). Basal cell (basaloid) carcinoma of the lung: A new morphologic and phenotypic entity with separate prognostic significance. Human Pathology, 23, 993–1003.

    Article  CAS  PubMed  Google Scholar 

  • Brambilla, C. G., Laffaire, J., Lantuejoul, S., et al. (2014). Lung squamous cell carcinomas with basaloid histology represent a specific molecular entity. Clinical Cancer Research, 20, 5777–5786.

    Article  CAS  PubMed  Google Scholar 

  • Moro-Sibilot, D., Lantuejoul, S., Diab, S., et al. (2008). Lung carcinomas with a basaloid pattern: A study of 90 cases focusing on their poor prognosis. The European Respiratory Journal, 31, 854–859.

    Article  CAS  PubMed  Google Scholar 

  • Wang, L. C., Wang, L., Kwauk, S., et al. (2011). Analysis on the clinical features of 22 basaloid squamous cell carcinoma of the lung. Journal of Cardiothoracic Surgery, 6, 10–15.

    Article  PubMed  PubMed Central  Google Scholar 

  • Travis, W. D., Brambilla, E., Burke, A. P., Marx, A., & Nicholson, A. N. (Eds.). (2015). WHO classification of tumours of the lung, pleura, thymus and heart. Geneva: WHO Press.

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Author information

Authors and Affiliations

  1. Department of Pathology, Aberdeen University Medical School, Aberdeen Royal Infirmary, Foresterhill, AB25 2ZD, Aberdeen, UK

    Keith M Kerr

Authors
  1. Keith M Kerr
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Correspondence to Keith M Kerr .

Editor information

Editors and Affiliations

  1. NIJMEGEN, The Netherlands

    J.H.J.M. van Krieken

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© 2017 Springer International Publishing AG

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Kerr, K.M. (2017). Basaloid Carcinoma, Lung. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4349-1

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  • DOI: https://doi.org/10.1007/978-3-319-28845-1_4349-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-28845-1

  • Online ISBN: 978-3-319-28845-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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