Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Adenocarcinoma, Lung

  • Keith M KerrEmail author
  • Gavin M Laing
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_4336-1

Synonyms

Definition

Invasive adenocarcinoma is a malignant epithelial tumor showing glandular differentiation, mucin production, or “pneumocyte marker” expression determined by immunohistochemistry (IHC). Patterns of glandular differentiation which are associated with adenocarcinoma subtypes are lepidic, acinar, papillary, micropapillary, and solid.

Clinical Features

Incidence and Etiology

Lung cancer in general is the commonest cause of lung cancer globally, and adenocarcinoma is the most common form of lung cancer in global terms. In the USA, the lung cancer incidence rate is approximately 35 cases per 100,000 person-years, but such figures are of questionable value given the considerable variations, largely due to regional variance in tobacco consumption. In several European countries, this figure can...

This is a preview of subscription content, log in to check access.

References and Further Reading

  1. Devarakona, S., Morgensztern, D., & Govindan, R. (2015). Genomic alterations in lung adenocarcinoma. Lancet Oncology, 16, e342–e351.CrossRefGoogle Scholar
  2. Greulich, H. (2011). The genomics of lung adenocarcinoma: Opportunities for targeted therapies. Genes & Cancer, 1, 1200–1210.CrossRefGoogle Scholar
  3. Imielinski, M., Berger, A. H., Hammerman, P., et al. (2012). Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell, 150, 1107–1120.CrossRefPubMedPubMedCentralGoogle Scholar
  4. Kerr, K. M. (2009). Pulmonary adenocarcinoma: Classification and reporting. Histopathology, 54, 12–27.CrossRefPubMedGoogle Scholar
  5. Travis, W. D., Brambilla, E., Noguchi, M., et al. (2011). International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society international multidisciplinary classification of lung adenocarcinoma. Journal of Thoracic Oncology, 6(2), 244–285.CrossRefPubMedPubMedCentralGoogle Scholar
  6. Travis, W. D., Brambilla, E., Noguchi, M., et al. (2013). Diagnosis of lung cancer in small biopsies and cytology: Implications of the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society Classification. Archives of Pathology & Laboratory Medicine, 137, 668–684.CrossRefGoogle Scholar
  7. Travis, W. D., Brambilla, E., Burke, A. P., Marx, A., & Nicholson, A. N. (Eds.). (2015). WHO classification of tumours of the lung, pleura, thymus and heart. Geneva: WHO press.Google Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of PathologyAberdeen University Medical School, Aberdeen Royal InfirmaryAberdeenUK
  2. 2.Department of PathologyAberdeen Royal InfirmaryAberdeenUK