Encyclopedia of Pathology

Living Edition
| Editors: J.H.J.M. van Krieken

Adenosquamous Carcinoma, Lung

  • Keith M KerrEmail author
  • Gavin M Laing
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-28845-1_4322-1


Mixed glandular and squamous carcinoma


An invasive carcinoma showing components of both invasive adenocarcinoma and squamous cell carcinoma. The lesser component should still comprise at least 10% of the tumor overall. Thus, adenosquamous carcinoma is a diagnosis that can only be made definitively in surgically resected cases where the whole tumor can be examined.

Clinical Features

  • Incidence

    Adenosquamous carcinoma of the lung is a relatively rare subtype, although figures for incidence vary widely due, historically, to a range of different diagnostic criteria being used to make the diagnosis. Figures quoted range from 0.4% to 5% of lung carcinomas. Given that it is a diagnosis that may only be confirmed in surgically resected series, the true incidence in all lung cancer patients, the majority of whom never have a surgical resection, could be rather different. As with most other nonsmall cell carcinomas (NSCLC), there is an association with smoking tobacco.

  • Age


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References and Further Readings

  1. Watababe, Y., Tsuta, K., Kusumoto, M., et al. (2014). Clinicopathological features and computed tomographic findings of 52 surgically resected adenosquamous carcinomas of the lung. Annals of Thoracic Oncology, 97, 245–251.CrossRefGoogle Scholar
  2. Watababe, Y., Shiraishi, K., Takahashi, F., et al. (2015). Biomarker expression and druggable genomic alterations for development of an appropriate therapeutic protocol for pulmonary adenosquamous carcinoma. Histopathology, 66, 939–948.CrossRefGoogle Scholar
  3. Travis, W. D., Brambilla, E., Burke, A. P., Marx, A., & Nicholson, A. N. (Eds.). (2015). WHO classification of tumours of the lung, pleura, thymus and heart. Geneva: WHO Press.Google Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of PathologyAberdeen University Medical School, Aberdeen Royal InfirmaryAberdeenUK